期刊
ACS OMEGA
卷 6, 期 18, 页码 12375-12381出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.1c01609
关键词
-
资金
- Department of Chemistry and Biochemistry of Miami University
Research has shown that dendritic materials with urethane linkages are more stable than those with other functional groups, and the use of a protecting group-free onepot multicomponent Curtius reaction allows for the construction of dendritic polyurethanes with late-stage modification, resulting in surface-functionalized polyurethane dendrimers.
Dendritic materials possessing urethane linkage are surprisingly more stable than similar structures having functional groups such as ether, ester, amide, or carbosilane. This generates profound interest in dendritic polyurethanes. Construction of a well-defined polyurethane dendrimer is, however, challenging because of isocyanates' high reactivity. As a model of our ongoing dendrimer-research, herein, we report a protecting group-free onepot multicomponent Curtius reaction to furnish a robust and versatile AB(2)-type dendron, which ensures late-stage modification of both the dendron and dendritic macromolecule yielding a surface functionalized polyurethane dendrimer. While 5-hydroxyisophthalic acid, 11-bromoundecanol, and 4-penten-1-ol were utilized in the construction of the dendron, thiol-ene click chemistry was employed for the late-stage modification. Novel dendrons and dendrimers synthesized were characterized by NMR (1D and 2D) and high-resolution MALDI-TOF analysis. This strategy allows an easy late-stage modification of dendritic macromolecules and is highly useful in the synthesis of both symmetrical and unsymmetrical dendrimers (Janus dendrimers).
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