期刊
ACS OMEGA
卷 6, 期 16, 页码 10963-10974出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.1c00764
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资金
- Freistaat Thuringen (Thuringer Ministerium fur Wirtschaft, Wissenschaft und Digitale Gesellschaft, TMWWDG), Germany
- Deutsche Forschungsgemeinschaft (DFG, Germany) [NG 133/1-2]
Controlling platelet-surface activation is challenging, but hydrogel films based on agarose and gelatin show promise in inhibiting platelet adhesion. Agarose films exhibit higher surface wettability, better controlled-swelling properties, and greater stiffness compared to gelatin, resulting in a strong reduction of platelet adhesion. The addition of magnetite nanoparticles to vary mechanical properties and surface wettability of the hydrogel films further enhances the inhibition of platelet adhesion and activation.
Platelet-surface interaction is of paramount importance in biomedical applications as well as in vitro studies. However, controlling platelet-surface activation is challenging and still requires more effort as they activate immediately when contacting with any nonphysiological surface. As hydrogels are highly biocompatible, in this study, we developed agarose and gelatin-based hydrogel films to inhibit platelet-surface adhesion. We found promising agarose films that exhibit higher surface wettability, better controlled-swelling properties, and greater stiffness compared to gelatin, resulting in a strong reduction of platelet adhesion. Mechanical properties and surface wettability of the hydrogel films were varied by adding magnetite (Fe3O4) nanoparticles. While all of the films prevented platelet spreading, films formed by agarose and its nanocomposite repelled platelets and inhibited platelet adhesion and activation stronger than those of gelatin. Our results showed that platelet-surface activation is modulated by controlling the properties of the films underneath platelets and that the bioinert agarose can be potentially translated to the development of platelet storage and other medical applications.
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