期刊
BRAIN SCIENCES
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/brainsci11040500
关键词
deep brain stimulation; gait; balance; cell therapy; Parkinson's disease
资金
- Ann Hanley Parkinson's Research Fund
- UK College of Medicine BRAIN Alliance
- Tom Dupree for Parkinson's Disease Research
- Pro's Players For Parkinson's
- Werner Schmitt endowment for Neurobehavior and Aging
- National Center for Advancing Translational Sciences [UL1TR001998]
A study on the effects of APNG implantation on gait and balance assessments in individuals with Parkinson's disease showed no significant deterioration in performance over two years, with improvement observed in the two most severely affected participants. Further research is needed to address the long-term maintenance of these results.
Background: The efficacy of deep brain stimulation (DBS) and dopaminergic therapy is known to decrease over time. Hence, a new investigational approach combines implanting autologous injury-activated peripheral nerve grafts (APNG) at the time of bilateral DBS surgery to the globus pallidus interna. Objectives: In a study where APNG was unilaterally implanted into the substantia nigra, we explored the effects on clinical gait and balance assessments over two years in 14 individuals with Parkinson's disease. Methods: Computerized gait and balance evaluations were performed without medication, and stimulation was in the off state for at least 12 h to best assess the role of APNG implantation alone. We hypothesized that APNG might improve gait and balance deficits associated with PD. Results: While people with a degenerative movement disorder typically worsen with time, none of the gait parameters significantly changed across visits in this 24 month study. The postural stability item in the UPDRS did not worsen from baseline to the 24-month follow-up. However, we measured gait and balance improvements in the two most affected individuals, who had moderate PD. In these two individuals, we observed an increase in gait velocity and step length that persisted over 6 and 24 months. Conclusions: Participants did not show worsening of gait and balance performance in the off therapy state two years after surgery, while the two most severely affected participants showed improved performance. Further studies may better address the long-term maintanenace of these results.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据