期刊
FRONTIERS IN MEDICINE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2021.638750
关键词
mean platelet volume; systemic lupus erythematosus; autoimmunity; platelets; biomarkers
资金
- Royal Swedish Academy of Sciences
- Swedish Research Council
- King Gustaf V's 80th Birthday Foundation
- Professor Nanna Svartz Foundation
- Gunvor and Josef Aners Foundation
- Pharmacist Hedberg Foundation
- Lars Hierta Memory Foundation
- Thelma Zoegas Foundation for Medical Research
- Alfred Osterlund's Foundation
- Anna-Greta Crafoord Foundation
- Greta and Johan Kock's Foundation
- Lund University Hospital
- Swedish Rheumatism Association
- Knut and Alice Wallenberg foundation
- Medical Faculty of Lund University
Platelets play important roles in SLE as immune modulators, with smaller MPV values in SLE patients compared to controls. Individual MPV variation was low, and fluctuations in disease activity did not significantly impact MPV over time. Further studies are needed to evaluate MPV as a biomarker in SLE and to determine underlying mechanisms affecting platelet size.
Platelets have recently emerged as important immune modulators in systemic lupus erythematosus (SLE), in addition to their role in thrombosis and cardiovascular disease. However, studies investigating mean platelet volume (MPV) in SLE are often scarce, conflicting and cross-sectional. In this study, MPV was measured in clinical routine throughout a defined time-period to quantify both individual MPV fluctuations and investigate if such variations are associated with disease activity and clinical phenotypes of SLE. Of our 212 patients, 34 patients had only one MPV value reported with the remaining 178 patients having between 2 and 19 visits with recorded MPV values. The intra-individual MPV variation was low, with a median variation of 0.7 fL. This was further supported by the finding that 84% of patients stayed within their reference interval category (i.e., small, normal or large) over time. In our cohort, no correlation between disease activity and MPV neither cross-sectionally nor longitudinally was found. Mean platelet volume values were significantly smaller in SLE patients (mean 10.5 fL) compared to controls (mean 10.8 fL), p < 0.0001. Based on the reference interval, 2.4% (n = 5) of patients had large-sized platelets, 84.4% (n = 179) had normal-sized and 13.2% (n = 28) had small-sized. A larger proportion (85.7%) of patients with small-sized platelets met the anti-dsDNA criterion (ACR10b; p = 0.003) compared to patients with normal and large (57.6%) sized platelets. In conclusion, the intra-individual MPV variation was of low magnitude and fluctuations in disease activity did not have any significant impact on MPV longitudinally. This lack of variability in MPV over time indicates that measuring MPV at any time-point is sufficient. Further studies are warranted to evaluate MPV as a possible biomarker in SLE, as well as to determine the underlying mechanisms influencing platelet size in SLE.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据