期刊
PATHOGENS
卷 10, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/pathogens10050521
关键词
African swine fever virus; Russian isolates; full-genome sequence; phylogenetic analysis; genome markers
类别
This study conducted full genome phylogenetic analysis on ASFV isolates from wild boars in Russia, revealing their genetic relationship and geographical distribution. Three single locus targets were identified as potential molecular markers with high resolving power for future ASFV phylogenetic practices.
In this study, we report on the full genome phylogenetic analysis of four ASFV isolates obtained from wild boars in Russia. These samples originated from two eastern and two western regions of Russia in 2019. Phylogenetic analysis indicated that the isolates were assigned to genotype II and grouped according to their geographical origins. The two eastern isolates shared 99.99% sequence identity with isolates from China, Poland, Belgium, and Moldova, whereas the western isolates had 99.98% sequence identity with isolates from Lithuania and the original Georgia 2007 isolate. Based on the full genome phylogenies, we identified three single locus targets, MGF-360-10L, MGF-505-9R, and I267L, that yielded the same resolving power as the full genomes. The ease of alignment and a high level of variation make these targets a suitable selection as additional molecular markers in future ASFV phylogenetic practices.
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