期刊
PATHOGENS
卷 10, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/pathogens10040467
关键词
APEC; virulence; pathogenesis; zoonosis; antibiotic resistance; vaccines; virulence inhibitors; infections
类别
资金
- U.S. Department of Agriculture [2015-68004-23131, 2020-6701-31401]
- Center for Food Animal Health, Department of Animal Sciences, The Ohio State University
APEC is a pathogen that causes colibacillosis in avian species, potentially posing a foodborne zoonotic risk. In addition to known virulence factors, other factors contribute to APEC pathogenesis. APEC shows resistance to multiple classes of antibiotics, highlighting the need for effective vaccines and alternative therapies.
Avian pathogenic Escherichia coli (APEC) causes colibacillosis in avian species, and recent reports have suggested APEC as a potential foodborne zoonotic pathogen. Herein, we discuss the virulence and pathogenesis factors of APEC, review the zoonotic potential, provide the current status of antibiotic resistance and progress in vaccine development, and summarize the alternative control measures being investigated. In addition to the known virulence factors, several other factors including quorum sensing system, secretion systems, two-component systems, transcriptional regulators, and genes associated with metabolism also contribute to APEC pathogenesis. The clear understanding of these factors will help in developing new effective treatments. The APEC isolates (particularly belonging to ST95 and ST131 or O1, O2, and O18) have genetic similarities and commonalities in virulence genes with human uropathogenic E. coli (UPEC) and neonatal meningitis E. coli (NMEC) and abilities to cause urinary tract infections and meningitis in humans. Therefore, the zoonotic potential of APEC cannot be undervalued. APEC resistance to almost all classes of antibiotics, including carbapenems, has been already reported. There is a need for an effective APEC vaccine that can provide protection against diverse APEC serotypes. Alternative therapies, especially the virulence inhibitors, can provide a novel solution with less likelihood of developing resistance.
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