4.5 Review

Zur: Zinc-Sensing Transcriptional Regulator in a Diverse Set of Bacterial Species

期刊

PATHOGENS
卷 10, 期 3, 页码 -

出版社

MDPI
DOI: 10.3390/pathogens10030344

关键词

Zinc (Zn); Zn homeostasis; Zinc uptake regulator (Zur); Zur regulon; transcriptional factor

资金

  1. Department of Biotechnology (DBT), India

向作者/读者索取更多资源

Zinc is an essential metal for all living organisms, but excess can be harmful. Living organisms have developed proteins that can track metal ion levels to provide survival advantages in different environmental conditions.
Zinc (Zn) is the quintessential d block metal, needed for survival in all living organisms. While Zn is an essential element, its excess is deleterious, therefore, maintenance of its intracellular concentrations is needed for survival. The living organisms, during the course of evolution, developed proteins that can track the limitation or excess of necessary metal ions, thus providing survival benefits under variable environmental conditions. Zinc uptake regulator (Zur) is a regulatory transcriptional factor of the FUR superfamily of proteins, abundant among the bacterial species and known for its intracellular Zn sensing ability. In this study, we highlight the roles played by Zur in maintaining the Zn levels in various bacterial species as well as the fact that in recent years Zur has emerged not only as a Zn homeostatic regulator but also as a protein involved directly or indirectly in virulence of some pathogens. This functional aspect of Zur could be exploited in the ventures for the identification of newer antimicrobial targets. Despite extensive research on Zur, the insights into its overall regulon and its moonlighting functions in various pathogens yet remain to be explored. Here in this review, we aim to summarise the disparate functional aspects of Zur proteins present in various bacterial species.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据