期刊
ESC HEART FAILURE
卷 8, 期 3, 页码 2232-2239出版社
WILEY PERIODICALS, INC
DOI: 10.1002/ehf2.13315
关键词
Diastolic function; COVID-19; Myocarditis; Echocardiography; Heart failure
资金
- APHP.centre
- INSERM
- French National Research Agency [ANR-17-CE17-0015-02, ANR-18-CE14-0032-01, ANR-19-CE170013-02]
- BPIFrance [2018-PSPC-07]
- ERA-Net-CVD [ANR-16-ECVD-0011-03]
- Federation Francaise de Cardiologie
- Fondation pour la Recherche Medicale
- Leducq Foundation [18CVD05]
- Research Federation Against Heart Failure (FHU2019, PREVENT_Heart Failure)
- H2020 INSIDE
- ARTERY
- APHP
- RAF vEDS
- Agence Nationale de la Recherche (ANR) [ANR-16-ECVD-0011, ANR-18-CE14-0032] Funding Source: Agence Nationale de la Recherche (ANR)
Significant cardiac diastolic abnormalities are observed in patients who experienced myocardial injury six months after the acute COVID-19 phase, but not in patients without cardiac involvement.
Aims Myocardial injury is frequently observed in patients hospitalized with coronavirus disease 2019 (COVID-19) pneumonia. Different cardiac abnormalities have been reported during the acute COVID-19 phase, ranging from infra-clinic elevations of myocardial necrosis biomarkers to acute cardiac dysfunction and myocarditis. There is limited information on late cardiac sequelae in patients who have recovered from acute COVID-19 illness. We aimed to document the presence and quantify the extent of myocardial functional alterations in patients hospitalized 6 months earlier for COVID-19 infection. Methods and results We conducted a prospective echocardiographic evaluation of 48 patients (mean age 58 +/- 13 years, 69% male) hospitalized 6 +/- 1 month earlier for a laboratory-confirmed and symptomatic COVID-19. Thirty-two (66.6%) had pre-existing cardiovascular risks factors (systemic hypertension, diabetes, or dyslipidaemia), and three patients (6.2%) had a known prior myocardial infarction. Sixteen patients (33.3%) experienced myocardial injury during the index COVID-19 hospitalization as identified by a rise in cardiac troponin levels. Six months later, 60.4% of patients still reported clinical symptoms including exercise dyspnoea for 56%. Echocardiographic measurements under resting conditions were not different between patients with versus without myocardial injury during the acute COVID-19 phase. In contrast, low-level exercise (25W for 3 min) induced a significant increase in the average E/e ' ratio (10.1 +/- 4.3 vs. 7.3 +/- 11.5, P = 0.01) and the systolic pulmonary artery pressure (33.4 +/- 7.8 vs. 25.6 +/- 5.3 mmHg, P = 0.02) in patients with myocardial injury during the acute COVID-19 phase. Sensitivity analyses showed that these alterations of left ventricular diastolic markers were observed regardless of whether of cardiovascular risk factors or established cardiac diseases indicating SARS-CoV-2 infection as a primary cause. Conclusions Six months after the acute COVID-19 phase, significant cardiac diastolic abnormalities are observed in patients who experienced myocardial injury but not in patients without cardiac involvement.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据