期刊
FRONTIERS IN MOLECULAR BIOSCIENCES
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2021.648663
关键词
PI3K inhibition; breast cancer; immune checkpoint inhibitors; MDSC; tumor immune microenvironment
资金
- VA Senior Career Scientist Award
This review discusses the role of PI3K pathway in breast cancer, evaluates the clinical development of PI3K inhibitors in early and metastatic breast cancer settings, and examines the evidence for the potential synergistic benefit of combination treatment with PI3K inhibition and immunotherapy in breast cancer treatment.
Dysregulation of phosphoinositide 3-kinase (PI3K) signaling is highly implicated in tumorigenesis, disease progression, and the development of resistance to the current standard of care treatments in breast cancer patients. This review discusses the role of PI3K pathway in breast cancer and evaluates the clinical development of PI3K inhibitors in both early and metastatic breast cancer settings. Further, this review examines the evidence for the potential synergistic benefit for the combination treatment of PI3K inhibition and immunotherapy in breast cancer treatment.
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