期刊
FRONTIERS IN MOLECULAR BIOSCIENCES
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2021.668910
关键词
ClpB chaperone; stress response; heat shock; type VI secretion; ClpB inhibitor
资金
- Swedish Research Council, Medicine and Health [2020-01362]
- Region Vasterbotten (Spjutspetsmedel) [VLL-582571]
- Region Vasterbotten (Centrala ALF-medel) [RV-939171]
- Swedish Research Council [2020-01362] Funding Source: Swedish Research Council
Bacterial survival within a mammalian host relies on sensing environmental perturbations and initiating appropriate counter-responses, where bacterial chaperone systems, particularly ClpB, play indispensable roles. ClpB is crucial for bacterial survival under various stress conditions, especially heat shock, and also regulates secretion of bacterial effector molecules related to type VI secretion systems.
Bacterial survival within a mammalian host is contingent upon sensing environmental perturbations and initiating an appropriate counter-response. To achieve this, sophisticated molecular machineries are used, where bacterial chaperone systems play key roles. The chaperones are a prerequisite for bacterial survival during normal physiological conditions as well as under stressful situations, e.g., infection or inflammation. Specific stress factors include, but are not limited to, high temperature, osmolarity, pH, reactive oxidative species, or bactericidal molecules. ClpB, a member of class 1 AAA(+) proteins, is a key chaperone that via its disaggregase activity plays a crucial role for bacterial survival under various forms of stress, in particular heat shock. Recently, it has been reported that ClpB also regulates secretion of bacterial effector molecules related to type VI secretion systems. In this review, the roles of ClpB in stress responses and the mechanisms by which it promotes survival of pathogenic bacteria are discussed.
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