期刊
FRONTIERS IN MOLECULAR BIOSCIENCES
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2021.683767
关键词
sphingolipids; sphingosine-1-phosphate; sphingosine kinase 2; nuclear lipids; aging
资金
- National Institute of Neurological Disorders and Stroke [R01NS115886]
S1P, a bioactive lipid molecule synthesized by SPHK1 and SPHK2, plays key roles in various signaling pathways, with SPHK2 regulating processes in the nucleus and mitochondria. Investigation into SPHK2 as a target for age-associated conditions is ongoing.
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and sphingosine kinase 2 (SPHK2), synthesize S1P by phosphorylating sphingosine. While SPHK1 is a cytoplasmic kinase, SPHK2 is localized to the nucleus, endoplasmic reticulum, and mitochondria. The SPHK2/S1P pathway regulates transcription, telomere maintenance, mitochondrial respiration, among many other processes. SPHK2 is under investigation as a target for treating many age-associated conditions, such as cancer, stroke, and neurodegeneration. In this review, we will focus on the role of SPHK2 in health and disease.
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