期刊
ANNALS OF TRANSLATIONAL MEDICINE
卷 9, 期 6, 页码 -出版社
AME PUBLISHING COMPANY
DOI: 10.21037/atm-20-4602
关键词
Heart failure (HF); preserved ejection fraction; pharmacotherapy; comorbidities
Heart failure with preserved ejection fraction (HFpEF) is a condition characterized by clinical signs and/or symptoms of heart failure with a left ventricular ejection fraction (LVEF) ≥50%. Risk factors associated with this disease include hypertension, hyperlipidemia, atrial fibrillation (AF), obesity, diabetes and coronary artery disease (CAD). Despite the presence of multiple risk factors, treatment and management for HFpEF remain challenging and are subject to ongoing research.
Heart failure with preserved ejection fraction (HFpEF) is the presence of clinical signs and/ or symptoms of heart failure with a left ventricular ejection fraction (LVEF) ?50%. Risk factors associated with this disease include hypertension, hyperlipidemia, atrial fibrillation (AF), obesity, diabetes and coronary artery disease (CAD). Despite the multiple risk factors identified for this condition, treatment and management remain challenging and a subject of ongoing research. Since a treatment approach that alters the natural course or lowers mortality for this disease has not been found, treating co-morbidities and symptom management is essential. From the comorbidities, hypertension is identified as the main risk factor for disease development. Thus, after congestive symptom control with diuretics, blood pressure (BP) management is considered one of the most important preventive measures and also a target for treatment. Amongst antihypertensives, angiotensin receptor blockers (ARBs) and aldosterone antagonists are the therapeutic agents used that have a role in reducing hospitalizations. Implantable monitoring devices have also been shown to reduce hospitalizations in comparison to standard heart failure therapies by allowing to tailor diuretic therapy based on ongoing hemodynamic data. In this manuscript we discuss pharmacologic strategies for HFpEF patients by risk factors, including those with and without a potential role.
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