期刊
MICROORGANISMS
卷 9, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms9050915
关键词
antibiotic; extremely low birth weight; feeding intolerance; human milk oligosaccharide; Lactobacillus reuteri; premature; probiotic; randomised controlled trial
类别
资金
- Swedish Research Council [921.2014-7060]
- Swedish Society for Medical Research
- Swedish Society of Medicine
- Research Council for Southeast Sweden
- ALF Grants
- Ekhaga Foundation
- BioGaia, Stockholm, Sweden
- Region Ostergotland
The study showed that Lactobacillus reuteri DSM 17938 supplementation leads to successful colonisation in extremely low birth weight infants, with a potential improvement in head growth for preterm ELBW infants.
Lactobacillus reuteri DSM 17938 supplementation reduces morbidities in very low birth weight infants (<1500 g), while the effect on extremely low birth weight infants (ELBW, <1000 g) is still questioned. In a randomised placebo-controlled trial (ClinicalTrials.gov ID NCT01603368), head growth, but not feeding tolerance or morbidities, improved in L. reuteri-supplemented preterm ELBW infants. Here, we investigate colonisation with the probiotic strain in preterm ELBW infants who received L. reuteri DSM 17938 or a placebo from birth to postmenstrual week (PMW) 36. Quantitative PCR was used on 582 faecal DNA samples collected from 132 ELBW infants at one, two, three, and four weeks, at PMW 36, and at two years of age. Human milk oligosaccharides were measured in 31 milk samples at two weeks postpartum. At least 86% of the ELBW infants in the L. reuteri group were colonised with the probiotic strain during the neonatal period, despite low gestational age, high antibiotic pressure, and independent of infant feeding mode. Higher concentrations of lacto-N-tetraose, sialyl-lacto-N-neotetraose c, and 6 '-sialyllactose in mother's milk weakly correlated with lower L. reuteri abundance. Within the L. reuteri group, higher L. reuteri abundance weakly correlated with a shorter time to reach full enteral feeding. Female sex and L. reuteri colonisation improved head growth from birth to four weeks of age. In conclusion, L. reuteri DSM 17938 supplementation leads to successful colonisation in ELBW infants.
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