期刊
ANTIOXIDANTS
卷 10, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/antiox10050650
关键词
diet; inflammation; oleocanthal; oxidative stress; rheumatoid arthritis; secoiridoid
资金
- Ministerio de Economia y Competitividad of Spain [AG-2017-89342-P]
- Junta de Andalucia [CTS259, FQM134]
- Postgraduate Program of PIF fellowship
- VI Plan Propio de Investigacion y Transferencia at the University of Seville
The study demonstrates that dietary supplementation of Oleocanthal can prevent collagen-induced arthritis in a murine model by reducing inflammation and providing protective antioxidant effects. Oleocanthal regulates the production of inflammatory and oxidative mediators, potentially serving as a novel dietary tool for preventing autoimmune and inflammatory disorders such as rheumatoid arthritis.
Oleocanthal (OLE), a characteristic and exclusive secoiridoid of Oleoaceae family, is mainly found in extra virgin olive oil (EVOO). Previous studies have reported its antioxidant, anti-inflammatory, antimicrobial, anticancer and neuroprotective effects. Since the pathogenesis of rheumatoid arthritis (RA) involves inflammatory and oxidative components, this study was designed to evaluate the preventive role of dietary OLE-supplemented effects in collagen-induced arthritis (CIA) murine model. Animals were fed with a preventive OLE-enriched dietary during 6 weeks previous to CIA induction and until the end of experiment time. At day 43 after first immunization, mice were sacrificed: blood was recollected and paws were histological and biochemically processed. Dietary OLE prevented bone, joint and cartilage rheumatic affections induced by collagen. Levels of circulatory matrix metalloproteinase (MMP)-3 and pro-inflammatory cytokines (IL-6, IL-1 beta, TNF-alpha, IL-17, IFN-gamma) were significantly decreased in secoiridoid fed animals. Besides, dietary OLE was able to diminish COX-2, mPGES-1 and iNOS protein expressions and, also, PGE(2) levels. The mechanisms underlying these protective effects could be related to Nrf-2/HO-1 axis activation and the inhibition of relevant signaling pathways including JAK-STAT, MAPKs and NF-kappa B, thus controlling the production of inflammatory and oxidative mediators. Overall, our results exhibit preliminary evidences about OLE, as a novel dietary tool for the prevention of autoimmune and inflammatory disorders, such as RA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据