期刊
ANTIOXIDANTS
卷 10, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/antiox10030473
关键词
bioactive compounds; phytochemicals; dietary fats; Mediterranean diet; PREDIMED-Plus study; plasma carotenoids; matrix effect absorption; liquid chromatography; mass spectrometry
资金
- CICYT [AGL2016-75329-R]
- CIBEROBN from the Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovacion y Universidades, (AEI/FEDER)
- Generalitat de Catalunya (GC) [2017SGR196]
- CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn)
- Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund [PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/01471, PI16/00473]
- Especial Action Project entitled Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant
- European Research Council [340918]
- Recercaixa grant [2013ACUP00194]
- Consejeria de Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016, PI0137/2018]
- Generalitat Valenciana [PROMETEO/2017/017]
- SEMERGEN grant
- Fundacio la Marato de TV3 [PI044003]
- Generalitat de Catalunya [2017 SGR 1717]
- CICYT grant by the Ministerio de Ciencia, Innovacion y Universidades [AGL2016-75329-R]
- European Regional Development Fund [CB06/03]
- FOLIUM program within the FUTURMed project entitled Talent for the medicine within the future from the Fundacio Institut d'Investigacio Sanitaria Illes Balears
- ICREA under the ICREA Academia programme
- FAPESP [2019/11324-8, 2013/07914-8]
- the Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund [PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00781, PI14/00728, PI16/00662, PI16/01873, PI16/01094]
- [FPU17/00513]
- [CD17/00122]
The study found that high consumers of fruits and vegetables had higher plasma carotenoid concentrations than low consumers, but circulating concentrations seemed to decrease when total fat intake was very high.
Carotenoids are pigments contained mainly in fruit and vegetables (F&V) that have beneficial effects on cardiometabolic health. Due to their lipophilic nature, co-ingestion of fat appears to increase their bioavailability via facilitating transfer to the aqueous micellar phase during digestion. However, the extent to which high fat intake may contribute to increased carotenoid plasma concentrations is still unclear. The objective was to examine the degree to which the consumption of different amounts of both carotenoid-rich foods and fats is associated with plasma carotenoid concentrations within a Mediterranean lifestyle context (subsample from the PREDIMED-Plus study baseline) where consumption of F&V and fat is high. The study population was categorized into four groups according to their self-reported consumption of F&V and fat. Carotenoids were extracted from plasma samples and analyzed by HPLC-UV-VIS-QqQ-MS/MS. Carotenoid systemic concentrations were greater in high consumers of F&V than in low consumers of these foods (+3.04 mu mol/L (95% CI: 0.90, 5.17), p-value = 0.005), but circulating concentrations seemed to decrease when total fat intake was very high (-2.69 mu mol/L (-5.54; 0.16), p-value = 0.064). High consumption of F&V is associated with greater systemic levels of total carotenoids, in particular when fat intake is low-to-moderate rather than very high.
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