期刊
ANTIOXIDANTS
卷 10, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/antiox10050698
关键词
Achillea millefolium; Arctium lappa; Asteraceae; hyaluronidase; Lamiaceae; lipoxygenase; reactive oxygen species; Thymus serpyllum
资金
- European Union under the European Regional Development Fund within the Operational Program Innovative economy
- for 2007-2013
The study aimed to determine the antioxidant activity of plant extracts traditionally used in Poland to treat inflammatory skin diseases. The extracts showed high free radical scavenging abilities but had a lower impact on enzyme activity. The main components of the extracts were flavonoids and caffeoylquinic acids.
A wide range of plant-derived preparations have been used against skin inflammatory disorders and as wound healing agents in traditional medicine. The purpose of the study was to determine the antioxidant activity of aqueous and 70% ethanolic extracts from eleven species of plants traditionally used in Poland to treat inflammatory skin diseases. The ability of extracts to scavenge 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), hydrogen peroxide (H2O2), and superoxide anion (O-2(center dot)-), was studied. In non-cellular studies, an analysis of the anti-inflammatory effect on the activity of enzymes, such as hyaluronidase (HYAL) and lipoxygenase (LOX), was also performed. The chemical profiles of the most active extracts were achieved by applying the UHPLC-DAD-MSn method, and the sum of polyphenols in all tested extracts was determined by the colorimetric method with the Folin-Ciocalteu reagent. The scope of the extracts' influence on enzyme activity was significantly lower than their antioxidant activity. All extracts have shown high activity in free radical scavenging against DPPH. The ethanolic extracts have shown high potential to scavenge H2O2. The study of composition showed that the main components of the tested extracts were flavonoids, such as luteolin, apigenin, kaempferol, and quercetin derivatives, as well as caffeoylquinic acids, caffeic acid, and its conjugates.
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