Complexity of the Nano-Bio Interface and the Tortuous Path of Metal Oxides in Biological Systems

Metal oxide nanoparticles (NPs) have received a great deal of attention as potential theranostic agents. Despite extensive work on a wide variety of metal oxide NPs, few chemically active metal oxide NPs have received Food and Drug Administration (FDA) clearance. The clinical translation of metal oxide NP activity, which often looks so promising in preclinical studies, has not progressed as rapidly as one might expect. The lack of FDA approval for metal oxide NPs appears to be a consequence of the complex transformation of NP chemistry as any given NP passes through multiple extra- and intracellular environments and interacts with a variety of proteins and transport processes that may degrade or transform the chemical properties of the metal oxide NP. Moreover, the translational models frequently used to study these materials do not represent the final therapeutic environment well, and studies in reduced preparations have, all too frequently, predicted fundamentally different physico-chemical properties from the biological activity observed in intact organisms. Understanding the evolving pharmacology of metal oxide NPs as they interact with biological systems is critical to establish translational test systems that effectively predict future theranostic activity.

Automated summary

Metal oxide nanoparticles have potential as theranostic agents, but the complexity of their chemistry as they interact with different environments and proteins may hinder their clinical translation. Inadequate translational models and discrepancies between simplified experiments and biological activities in organisms pose challenges for accurately predicting the therapeutic potential of metal oxide NPs. Understanding the evolving pharmacology of these NPs in biological systems is crucial for establishing effective translational test systems.