4.7 Review

Proteolytic Cleavage of Receptor Tyrosine Kinases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies

Yiyuan Xia et al.

Summary: Neurotrophins such as BDNF promote neuronal survival and synaptic plasticity by activating tropomyosin receptor kinases. Reduced levels of BDNF and its receptor TrkB in Alzheimer's disease contribute to cognitive decline. The research shows that the TrkB receptor phosphorylates APP, reducing amyloid-beta production, but this process is disrupted by delta-secretase cleavage in AD.

MOLECULAR PSYCHIATRY (2021)

Review Biochemistry & Molecular Biology

Gamma-secretase-dependent signaling of receptor tyrosine kinases

Johannes A. M. Merilahti et al.

ONCOGENE (2019)

Article Cell Biology

Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons

Christopher R. Donnelly et al.

JOURNAL OF CELL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Mechanisms of receptor tyrosine kinase activation in cancer

Zhenfang Du et al.

MOLECULAR CANCER (2018)

Article Multidisciplinary Sciences

The beta secretase BACE1 regulates the expression of insulin receptor in the liver

Paul J. Meakin et al.

NATURE COMMUNICATIONS (2018)

Article Cell Biology

Genome-wide screen of gamma-secretase-mediated intramembrane cleavage of receptor tyrosine kinases

Johannes A. M. Merilahti et al.

MOLECULAR BIOLOGY OF THE CELL (2017)

Article Multidisciplinary Sciences

Smek1/2 is a nuclear chaperone and cofactor for cleaved Wnt receptor Ryk, regulating cortical neurogenesis

Wen-Hsuan Chang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Endocrinology & Metabolism

Sequential cleavage of insulin receptor by calpain 2 and γ-secretase impairs insulin signalling

Tomoyuki Yuasa et al.

DIABETOLOGIA (2016)

Editorial Material Medicine, Research & Experimental

Tie1: an orphan receptor provides context for angiopoietin-2/Tie2 signaling

Sarah B. Mueller et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Neurosciences

Calpain-dependent truncated form of TrkB-FL increases in neurodegenerative processes

Victor Danelon et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2016)

Article Ophthalmology

Proangiogenic Interactions of Vascular Endothelial MMP14 With VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis

Kyu-Yeon Han et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2016)

Article Ophthalmology

MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect

Kyu-Yeon Han et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2015)

Article Biochemistry & Molecular Biology

Identification and mutagenesis of the TACE and γ-secretase cleavage sites in the colony-stimulating factor 1 receptor

Arrash Vahidi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

EphA4 Receptor Shedding Regulates Spinal Motor Axon Guidance

Graziana Gatto et al.

CURRENT BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Protein-tyrosine Pseudokinase 7 (PTK7) Directs Cancer Cell Motility and Metastasis

Vladislav S. Golubkov et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

The Eph Tyrosine Kinase Receptors EphB2 and EphA2 Are Novel Proteolytic Substrates of Tissue Factor/Coagulation Factor VIIa

Oskar Eriksson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

The Serine Protease Granzyme B as an Inflammatory Marker, in Relation to the Insulin Receptor Cleavage in Human Obesity and Type 2 Diabetes Mellitus

Hala O. El Mesallamy et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2014)

Article Endocrinology & Metabolism

Crosstalk Between Nuclear MET and SOX9/β-Catenin Correlates with Castration-Resistant Prostate Cancer

Yingqiu Xie et al.

MOLECULAR ENDOCRINOLOGY (2014)

Article Biochemistry & Molecular Biology

ADAM12-cleaved ephrin-A1 contributes to lung metastasis

K. Ieguchi et al.

ONCOGENE (2014)

Review Pharmacology & Pharmacy

The ErbB/HER family of protein-tyrosine kinases and cancer

Robert Roskoski

PHARMACOLOGICAL RESEARCH (2014)

Article Cell Biology

Insulin Receptor Signaling in Normal and Insulin-Resistant States

Jeremie Boucher et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases

Hsueh-Liang Fu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

The Dependence Receptor TrkC Triggers Mitochondria-Dependent Apoptosis upon Cobra-1 Recruitment

Gabriel Ichim et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

A Fully Human Inhibitory Monoclonal Antibody to the Wnt Receptor RYK

Michael M. Halford et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

ADAM-10 and-17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling

Miles A. Miller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biochemistry & Molecular Biology

Eph-dependent cell-cell adhesion and segregation in development and cancer

Eva Nievergall et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Article Biochemistry & Molecular Biology

Interaction with ErbB4 Promotes Hypoxia-inducible Factor-1α Signaling

Ilkka Paatero et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Insights into Ectodomain Shedding and Processing of Protein-tyrosine Pseudokinase 7 (PTK7)

Vladislav S. Golubkov et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Cell Biology

FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior

Athina-Myrto Chioni et al.

JOURNAL OF CELL BIOLOGY (2012)

Article Multidisciplinary Sciences

Proteolytic Processing of ErbB4 in Breast Cancer

Maija Hollmen et al.

PLOS ONE (2012)

Review Oncology

Spatial regulation of receptor tyrosine kinases in development and cancer

Jessica B. Casaletto et al.

NATURE REVIEWS CANCER (2012)

Article Biochemistry & Molecular Biology

Neuregulin Receptor ErbB4 Functions as a Transcriptional Cofactor for the Expression of Surfactant Protein B in the Fetal Lung

Katja Zscheppang et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Molecular control of angiopoietin signalling

Harprit Singh et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2011)

Article Biochemistry & Molecular Biology

Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation

Kristina Hoeing et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

Article Biochemistry & Molecular Biology

Estrogen-induced upregulation of Sftpb requires transcriptional control of neuregulin receptor ErbB4 in mouse lung type II epithelial cells

Katja Zscheppang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

Review Pharmacology & Pharmacy

Emerging strategies for EphA2 receptor targeting for cancer therapeutics

Manish Tandon et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2011)

Article Biochemistry & Molecular Biology

RET Modulates Cell Adhesion via Its Cleavage by Caspase in Sympathetic Neurons

Jorge R. Cabrera et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

γ-Secretase and Presenilin Mediate Cleavage and Phosphorylation of Vascular Endothelial Growth Factor Receptor-1

Jun Cai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Cell Biology

Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3

Catherine R. Degnin et al.

MOLECULAR BIOLOGY OF THE CELL (2011)

Article Biochemistry & Molecular Biology

Cell Signaling by Receptor Tyrosine Kinases

Mark A. Lemmon et al.

Article Biochemistry & Molecular Biology

A Disintegrin and Metalloproteinase-10 (ADAM-10) Mediates DN30 Antibody-induced Shedding of the Met Surface Receptor

Florian Schelter et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesis

Celine Furne et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)

Article Biochemistry & Molecular Biology

Cdc37 Regulates Ryk Signaling by Stabilizing the Cleaved Ryk Intracellular Domain

Jungmook Lyu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Editorial Material Cardiac & Cardiovascular Systems

VEGF-A Stimulates ADAM17-Dependent Shedding of VEGFR2 and Crosstalk Between VEGFR2 and ERK Signaling

Steven Swendeman et al.

CIRCULATION RESEARCH (2008)

Article Biochemistry & Molecular Biology

Caspase cleavage of HER-2 releases a bad-like cell death effector

Anne M. Strohecker et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Biochemistry & Molecular Biology

The ADAM metalloproteinases

Dylan R. Edwards et al.

MOLECULAR ASPECTS OF MEDICINE (2008)

Article Biochemistry & Molecular Biology

Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2

Marie B. Marron et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Generation of intracellular domain of insulin receptor tyrosine kinase by γ-secretase

K. Kasuga et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Multidisciplinary Sciences

The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm

Servane Tauszig-Delamasure et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Endocrinology & Metabolism

Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes

Toshiyuki Obata et al.

DIABETES (2007)

Article Cell Biology

Receptor tyrosine kinases: mechanisms of activation and signaling

Stevan R. Hubbard et al.

CURRENT OPINION IN CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis

Carly R. K. Loeb et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Cell Biology

The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells

Rebecca S. Muraoka-Cook et al.

MOLECULAR BIOLOGY OF THE CELL (2006)

Article Biochemistry & Molecular Biology

Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage

Jaouhar Mourali et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Oncology

c-Met ectodomain shedding rate correlates with malignant potential

Gagani Athauda et al.

CLINICAL CANCER RESEARCH (2006)

Article Biochemistry & Molecular Biology

Metalloproteinase/presenilin 1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling

A Georgakopoulos et al.

EMBO JOURNAL (2006)

Article Cell Biology

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

U Sahin et al.

JOURNAL OF CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage

D Tulasne et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Ectodomain cleavage of ErbB-4 - Characterization of the cleavage site and m80 fragment

QC Cheng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6

E Trivier et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Tumor necrosis factor-α converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability

SW Sunnarborg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Ligand-induced shedding of discoidin domain receptor 1

WF Vogel

FEBS LETTERS (2002)

Article Multidisciplinary Sciences

Regulated cleavage of a contact-mediated axon repellent

M Hattori et al.

SCIENCE (2000)

Article Biochemistry & Molecular Biology

The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease

MC Bordeaux et al.

EMBO JOURNAL (2000)

Article Biochemistry & Molecular Biology

Tumor necrosis factor-α-converting enzyme is required for cleavage of erbB4/HER4

C Rio et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)