The Impact of the Ca2+-Independent Phospholipase A2β (iPLA2β) on Immune Cells

The Ca2+-independent phospholipase A(2)beta (iPLA(2)beta) is a member of the PLA(2) family that has been proposed to have roles in multiple biological processes including membrane remodeling, cell proliferation, bone formation, male fertility, cell death, and signaling. Such involvement has led to the identification of iPLA(2)beta activation in several diseases such as cancer, cardiovascular abnormalities, glaucoma, periodontitis, neurological disorders, diabetes, and other metabolic disorders. More recently, there has been heightened interest in the role that iPLA(2)beta plays in promoting inflammation. Recognizing the potential contribution of iPLA(2)beta in the development of autoimmune diseases, we review this issue in the context of an iPLA(2)beta link with macrophages and T-cells.

Automated summary

iPLA(2)beta is involved in various biological processes, activated in several diseases, and plays a role in promoting inflammation, potentially contributing to the development of autoimmune diseases.