期刊
BIOMOLECULES
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/biom11040594
关键词
androgens; androgen receptor; bladder cancer; signaling pathways; therapies
资金
- Apoyo a Nuevos Profesores de Tiempo Completo del Programa para el Desarrollo Profesional Docente (PRODEP) [120218]
Bladder cancer is a common neoplasm that mainly affects men, with risk factors including smoking and exposure to chemicals. The androgen receptor has been shown to play a significant role in the initiation and development of bladder cancer.
Bladder cancer (urothelial carcinoma) is one of the most frequently diagnosed neoplasms, with an estimated half a million new cases and 200,000 deaths per year worldwide. This pathology mainly affects men. Men have a higher risk (4:1) of developing bladder cancer than women. Cigarette smoking and exposure to chemicals such as aromatic amines, and aniline dyes have been established as risk factors for bladder cancer and may contribute to the sex disparity. Male internal genitalia, including the urothelium and prostate, are derived from urothelial sinus endoderm; both tissues express the androgen receptor (AR). Several investigations have shown evidence that the AR plays an important role in the initiation and development of different types of cancer including bladder cancer. In this article, we summarize the available data that help to explain the role of the AR in the development and progression of bladder cancer, as well as the therapies used for its treatment.
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