期刊
BIOMOLECULES
卷 11, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/biom11050747
关键词
osteoclasts (OCs); bone resorption; osteoporosis; therapeutics; gene therapy
资金
- Key R&D projects of Shaanxi Province [2018SF-280, 2021SF-242]
- Youth talent project of Science Association of Colleges and Universities in Shaanxi Province [2019-2-10]
The article focuses on the importance of osteoclasts in bone metabolism and their relationship with osteoporosis, while also introducing some drug therapies targeting these molecules.
Osteoclasts (OCs) are important cells that are involved in the regulation of bone metabolism and are mainly responsible for coordinating bone resorption with bone formation to regulate bone remodeling. The imbalance between bone resorption and formation significantly affects bone metabolism. When the activity of osteoclasts exceeds the osteoblasts, it results in a condition called osteoporosis, which is characterized by reduced bone microarchitecture, decreased bone mass, and increased occurrences of fracture. Molecules, including transcription factors, proteins, hormones, nucleic acids, such as non-coding RNAs, play an important role in osteoclast proliferation, differentiation, and function. In this review, we have highlighted the role of these molecules in osteoclasts regulation and osteoporosis. The developed therapeutics targeting these molecules for the treatment of osteoporosis in recent years have also been discussed with challenges faced in clinical application.
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