期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2021.688477
关键词
agarose; alginate; chitosan; aerogel; supercritical CO2; drug delivery
This study analyzed drug delivery systems formed by polysaccharide-based aerogels, particularly focusing on the promising technique of supercritical CO2 assisted drying to produce nanostructured bio-aerogels. This technique allows for maintaining the starting gel volume and shape while removing cross-linking agent residues, making these advanced devices safe and suitable for controlled drug delivery applications.
In this short review, drug delivery systems, formed by polysaccharide-based (i.e., agarose, alginate, and chitosan) aerogels, are analyzed. In particular, the main papers, published in the period 2011-2020 in this research field, have been investigated and critically discussed, in order to highlight strengths and weaknesses of the traditional production techniques (e.g., freeze-drying and air evaporation) of bio-aerogels with respect to supercritical CO2 assisted drying. Supercritical CO2 assisted drying demonstrated to be a promising technique to produce nanostructured bio-aerogels that maintain the starting gel volume and shape, when the solvent removal occurs at negligible surface tension. This characteristic, coupled with the possibility of removing also cross-linking agent residues from the aerogels, makes these advanced devices safe and suitable as carriers for controlled drug delivery applications.
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