4.7 Review

Mitochondrial Control of Stem Cell State and Fate: Lessons From Drosophila

期刊

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.606639

关键词

Drosophila; metabolism; mitochondria; stem cell; regulation; maintenance; differentiation

向作者/读者索取更多资源

Over the years, Drosophila has been a valuable genetic model system to study tissue-resident stem cells, with recent advancements in understanding the contribution of mitochondria to governing stem cell properties.
Over the years, Drosophila has served as a wonderful genetically tractable model system to unravel various facets of tissue-resident stem cells in their microenvironment. Studies in different stem and progenitor cell types of Drosophila have led to the discovery of cell-intrinsic and extrinsic factors crucial for stem cell state and fate. Though initially touted as the ATP generating machines for carrying various cellular processes, it is now increasingly becoming clear that mitochondrial processes alone can override the cellular program of stem cells. The last few years have witnessed a surge in our understanding of mitochondria's contribution to governing different stem cell properties in their subtissular niches in Drosophila. Through this review, we intend to sum up and highlight the outcome of these in vivo studies that implicate mitochondria as a central regulator of stem cell fate decisions; to find the commonalities and uniqueness associated with these regulatory mechanisms.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据