期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.650772
关键词
Notch signaling; Hedgehog signaling; Wnt signaling; tumors; resistance; anticancer; therapy
资金
- Pudong New Area Science and Technology Development Grant [PKJ2019-Y09]
Resistance to therapy is a major challenge in cancer management, with cancer cells rewiring their cellular processes to resist the deleterious effects of various therapeutic approaches. Understanding the role of developmental pathways in cancer and their contribution to resistance can lead to insights for developing novel therapeutic approaches. Recognizing the importance of molecular networks in overcoming drug resistance can provide a rational basis for improving cancer treatment with safer and more effective combined therapeutic strategies.
Resistance to therapy is the major hurdle in the current cancer management. Cancer cells often rewire their cellular process to alternate mechanisms to resist the deleterious effect mounted by different therapeutic approaches. The major signaling pathways involved in the developmental process, such as Notch, Hedgehog, and Wnt, play a vital role in development, tumorigenesis, and also in the resistance to the various anticancer therapies. Understanding how cancer utilizes these developmental pathways in acquiring the resistance to the multi-therapeutic approach cancer can give rise to a new insight of the anti-therapy resistance mechanisms, which can be explored for the development of a novel therapeutic approach. We present a brief overview of Notch, Hedgehog, and Wnt signaling pathways in cancer and its role in providing resistance to various cancer treatment modalities such as chemotherapy, radiotherapy, molecular targeted therapy, and immunotherapy. Understanding the importance of these molecular networks will provide a rational basis for novel and safer combined anticancer therapeutic approaches for the improvement of cancer treatment by overcoming drug resistance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据