期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.662191
关键词
GABA(A) receptors; oligodendrocyte precursor cells; NG2 glia; myelination; remyelination; β -carbolines; neurosteroids
资金
- Consejo Nacional de Ciencia y Tecnologia (CONACYT) [1771, 360136]
- Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica-Universidad Nacional Autonoma de Mexico (PAPIIT-UNAM) [IN205718, IN209121, IN203519]
Oligodendrocytes play a crucial role in brain connectivity by producing myelin for insulating axons. Myelin repair relies on the differentiation of new oligodendrocytes from precursor cells to preserve and remodel myelin. Neuron-glia communication through GABA signaling in OPCs is important for myelin plasticity and repair.
Oligodendrocytes (OLs) produce myelin to insulate axons. This accelerates action potential propagation, allowing nerve impulse information to synchronize within complex neuronal ensembles and promoting brain connectivity. Brain plasticity includes myelination, a process that starts early after birth and continues throughout life. Myelin repair, followed by injury or disease, requires new OLs differentiated from a population derived from oligodendrocyte precursor cells (OPCs) that continue to proliferate, migrate and differentiate to preserve and remodel myelin in the adult central nervous system. OPCs represent the largest proliferative neural cell population outside the adult neurogenic niches in the brain. OPCs receive synaptic inputs from glutamatergic and GABAergic neurons throughout neurodevelopment, a unique feature among glial cells. Neuron-glia communication through GABA signaling in OPCs has been shown to play a role in myelin plasticity and repair. In this review we will focus on the molecular and functional properties of GABA(A) receptors (GABA(A)Rs) expressed by OPCs and their potential role in remyelination.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据