期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.635263
关键词
leukocyte; vascular endothelial cell; transednothelial migration; biomechanics; force microscopy
资金
- National Institutes of Health [GM084227]
- American Heart Association [18CDA34110462]
- Fundacion Bancaria 'la Caixa' [100010434]
- 'la Caixa' Fellowship [LCF/BQ/US12/10110011]
Leukocyte transendothelial migration is a critical process for innate immunity and inflammation, involving intricate steps of leukocytes passing through endothelial cell layers. Biomechanics plays a decisive role in this process, and recent technological advances enable the study of how cellular forces affect endothelial barrier integrity.
Leukocyte transendothelial migration is crucial for innate immunity and inflammation. Upon tissue damage or infection, leukocytes exit blood vessels by adhering to and probing vascular endothelial cells (VECs), breaching endothelial cell-cell junctions, and transmigrating across the endothelium. Transendothelial migration is a critical rate-limiting step in this process. Thus, leukocytes must quickly identify the most efficient route through VEC monolayers to facilitate a prompt innate immune response. Biomechanics play a decisive role in transendothelial migration, which involves intimate physical contact and force transmission between the leukocytes and the VECs. While quantifying these forces is still challenging, recent advances in imaging, microfabrication, and computation now make it possible to study how cellular forces regulate VEC monolayer integrity, enable efficient pathfinding, and drive leukocyte transmigration. Here we review these recent advances, paying particular attention to leukocyte adhesion to the VEC monolayer, leukocyte probing of endothelial barrier gaps, and transmigration itself. To offer a practical perspective, we will discuss the current views on how biomechanics govern these processes and the force microscopy technologies that have enabled their quantitative analysis, thus contributing to an improved understanding of leukocyte migration in inflammatory diseases.
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