期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.634118
关键词
autophagy; NLRP3 inflammasome; glucose metabolic disorders; uric acid metabolic disorders; inflammation-related metabolic disorders
资金
- Key Scientific and Technological Projects in Henan Province, China [202102310153]
- National Natural Science Foundation of China [81971280]
Autophagy is a crucial cellular pathway for maintaining cellular balance, while the interaction between autophagy and the NLRP3 inflammasome plays a significant role in various diseases, especially metabolic disorders.
Autophagy is an important and conserved cellular pathway in which cells transmit cytoplasmic contents to lysosomes for degradation. It plays an important role in maintaining the balance of cell composition synthesis, decomposition and reuse, and participates in a variety of physiological and pathological processes. The nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome can induce the maturation and secretion of Interleukin-1 beta (IL-1 beta) and IL-18 by activating caspase-1. It is involved in many diseases. In recent years, the interplay between autophagy and NLRP3 inflammasome has been reported to contribute to many diseases including metabolic disorders related diseases. In this review, we summarized the recent studies on the interplay between autophagy and NLRP3 inflammasome in metabolic disorders to provide ideas for the relevant basic research in the future.
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