4.7 Review

Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

Faustino Mollinedo et al.

JOURNAL OF LIPID RESEARCH (2020)

Article Biochemistry & Molecular Biology

MicroRNA 27a Is a Key Modulator of Cholesterol Biosynthesis

Abrar A. Khan et al.

MOLECULAR AND CELLULAR BIOLOGY (2020)

Review Cell Biology

Mechanisms and regulation of cholesterol homeostasis

Jie Luo et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate

Hiromasa Yoshioka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Medicine, Research & Experimental

From Warburg effect to Reverse Warburg effect; the new horizons of anticancer therapy

Sonu Benny et al.

MEDICAL HYPOTHESES (2020)

Review Oncology

Role of de novo cholesterol synthesis enzymes in cancer

Jie Yang et al.

JOURNAL OF CANCER (2020)

Article Medicine, Research & Experimental

Anti-cancer effect of doxorubicin is mediated by downregulation of HMG-Co A reductase via inhibition of EGFR/Src pathway

Un-Jung Yun et al.

LABORATORY INVESTIGATION (2019)

Editorial Material Multidisciplinary Sciences

The shape of human squalene epoxidase expands the arsenal against cancer

Andrew J. Brown et al.

NATURE COMMUNICATIONS (2019)

Article Endocrinology & Metabolism

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer

Joseph Longo et al.

MOLECULAR METABOLISM (2019)

Article Biochemistry & Molecular Biology

Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing[S]

Liang Chen et al.

JOURNAL OF LIPID RESEARCH (2019)

Review Medicine, Research & Experimental

Highlight article: The role of cholesterol and cholesterol-driven membrane raft domains in prostate cancer

Anita Hryniewicz-Jankowska et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2019)

Article Cell Biology

Mechanisms of Niemann-Pick type C1 Like 1 protein degradation in intestinal epithelial cells

Pooja Malhotra et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2019)

Review Oncology

Squalene epoxidase as a promising metabolic target in cancer treatment

Gabriella Cirmena et al.

CANCER LETTERS (2018)

Editorial Material Cell Biology

Cholesterol, cancer, and rebooting a treatment for athlete's foot

Ngee Kiat Chua et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Review Cell Biology

Mitochondria-associated ER membranes (MAMs) and lysosomal storage diseases

Ida Annunziata et al.

CELL DEATH & DISEASE (2018)

Review Biochemistry & Molecular Biology

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

Michael S. Brown et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Review Endocrinology & Metabolism

Sterol Metabolism and Transport in Atherosclerosis and Cancer

Yoshio Yamauchi et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Biochemistry & Molecular Biology

Emerging roles of lipid metabolism in cancer metastasis

Xiangjian Luo et al.

MOLECULAR CANCER (2017)

Review Biochemistry & Molecular Biology

Ligands of Therapeutic Utility for the Liver X Receptors

Rajesh Komati et al.

MOLECULES (2017)

Review Biochemistry & Molecular Biology

Interconnection of Estrogen/Testosterone Metabolism and Mevalonate Pathway in Breast and Prostate Cancers

Pooneh Mokarram et al.

CURRENT MOLECULAR PHARMACOLOGY (2017)

Review Pharmacology & Pharmacy

The emerging roles of liver X receptors and their ligands in cancer

Chin-Yo Lin et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2016)

Article Oncology

Cholesterol Metabolism and Prostate Cancer Lethality

Konrad H. Stopsack et al.

CANCER RESEARCH (2016)

Review Oncology

The Role of Cholesterol in Cancer

Omer F. Kuzu et al.

CANCER RESEARCH (2016)

Article Cardiac & Cardiovascular Systems

MicroRNA Regulation of Atherosclerosis

Mark W. Feinberg et al.

CIRCULATION RESEARCH (2016)

Article Biochemistry & Molecular Biology

Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division

Ankur A. Gholkar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Medicine, General & Internal

Hypertension, serum lipids and cancer risk: A review of epidemiological evidence

Ricardas Radisauskas et al.

MEDICINA-LITHUANIA (2016)

Article Multidisciplinary Sciences

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Paulina Bartuzi et al.

NATURE COMMUNICATIONS (2016)

Review Medicine, General & Internal

Hypertension, serum lipids and cancer risk: A review of epidemiological evidence

Ricardas Radisauskas et al.

MEDICINA-LITHUANIA (2016)

Article Biochemistry & Molecular Biology

Role of mitochondrial raft-like microdomains in the regulation of cell apoptosis

Tina Garofalo et al.

APOPTOSIS (2015)

Review Biochemistry & Molecular Biology

Cholesterol lowering: role in cancer prevention and treatment

Toshiyuki Murai

BIOLOGICAL CHEMISTRY (2015)

Review Oncology

Cell Membrane Fluid-Mosaic Structure and Cancer Metastasis

Garth L. Nicolson

CANCER RESEARCH (2015)

Article Biochemistry & Molecular Biology

Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum

Yoshio Yamauchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver

Xiujuan Zhang et al.

JOURNAL OF LIPID RESEARCH (2015)

Review Biochemistry & Molecular Biology

Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators

Maximillian A. Rogers et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis

Alexandre Wagschal et al.

NATURE MEDICINE (2015)

Article Multidisciplinary Sciences

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

Fabienne Guillaumond et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Oncology

Warburg Effect or Reverse Warburg Effect? A Review of Cancer Metabolism

Xiao Dong Xu et al.

ONCOLOGY RESEARCH AND TREATMENT (2015)

Review Oncology

Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer

Philip A. Watson et al.

NATURE REVIEWS CANCER (2015)

Review Cardiac & Cardiovascular Systems

Cholesterol confusion and statin controversy

Robert DuBroff et al.

WORLD JOURNAL OF CARDIOLOGY (2015)

Article Critical Care Medicine

Squalene Synthase Induces Tumor Necrosis Factor Receptor 1 Enrichment in Lipid Rafts to Promote Lung Cancer Metastasis

Yi-Fang Yang et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

Article Oncology

Obesity, Cholesterol Metabolism, and Breast Cancer Pathogenesis

Donald P. McDonnell et al.

CANCER RESEARCH (2014)

Article Cell Biology

LXR Agonist Regulates the Carcinogenesis of PCa via the SOCS3 Pathway

Weihua Fu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Cellular Cholesterol Efflux

Michael C. Phillips

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Cell Biology

Metabolic control of YAP and TAZ by the mevalonate pathway

Giovanni Sorrentino et al.

NATURE CELL BIOLOGY (2014)

Article Multidisciplinary Sciences

MicroRNA-223 coordinates cholesterol homeostasis

Kasey C. Vickers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Oncology

CAV-1 contributes to bladder cancer progression by inducing epithelial-to-mesenchymal transition

Wu Liang et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2014)

Article Medicine, General & Internal

Fifteen-Year Survival Outcomes Following Primary Androgen-Deprivation Therapy for Localized Prostate Cancer

Grace L. Lu-Yao et al.

JAMA INTERNAL MEDICINE (2014)

Article Oncology

Targeting cholesterol synthesis increases chemoimmuno-sensitivity in chronic lymphocytic leukemia cells

Indira Benakanakere et al.

EXPERIMENTAL HEMATOLGY & ONCOLOGY (2014)

Article Pharmacology & Pharmacy

5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells

Gregory Segala et al.

BIOCHEMICAL PHARMACOLOGY (2013)

Article Oncology

Notch3 is activated by chronic hypoxia and contributes to the progression of human prostate cancer

Giovanna Danza et al.

INTERNATIONAL JOURNAL OF CANCER (2013)

Article Biochemistry & Molecular Biology

Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

Ebru Boslem et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling

Elissaveta Petrova et al.

NATURE CHEMICAL BIOLOGY (2013)

Article Medicine, General & Internal

Statin Use and Reduced Cancer-Related Mortality

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Oncology

Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma

M. Reis-Sobreiro et al.

BLOOD CANCER JOURNAL (2013)

Article Oncology

Dietary cholesterol intake and cancer

J. Hu et al.

ANNALS OF ONCOLOGY (2012)

Article Cell Biology

Altered Mitochondrial Function and Metabolic Inflexibility Associated with Loss of Caveolin-1

Ingrid Wernstedt Asterholm et al.

CELL METABOLISM (2012)

Review Oncology

Novel Aspects of Mevalonate Pathway Inhibitors as Antitumor Agents

Martin Thurnher et al.

CLINICAL CANCER RESEARCH (2012)

Editorial Material Pharmacology & Pharmacy

Cholesterol metabolism and cancer: the good, the bad and the ugly

Sandrine Silvente-Poirot et al.

CURRENT OPINION IN PHARMACOLOGY (2012)

Article Pharmacology & Pharmacy

Cholesterol and prostate cancer

Kristine Pelton et al.

CURRENT OPINION IN PHARMACOLOGY (2012)

Article Cell & Tissue Engineering

Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target

Christophe Ginestier et al.

STEM CELLS (2012)

Review Endocrinology & Metabolism

MicroRNA Regulation of Cholesterol Metabolism

Noemi Rotllan et al.

CHOLESTEROL (2012)

Article Pathology

Role of Cholesterol in the Development and Progression of Breast Cancer

Gemma Llaverias et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Article Biochemistry & Molecular Biology

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

Timothy R. Peterson et al.

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Biochemical Research Methods

Lipid rafts: signaling and sorting platforms of cells and their roles in cancer

Simon Staubach et al.

EXPERT REVIEW OF PROTEOMICS (2011)

Article Biochemistry & Molecular Biology

Low Cholesterol Triggers Membrane Microdomain-dependent CD44 Shedding and Suppresses Tumor Cell Migration

Toshiyuki Murai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains

Xinxin Gao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemistry & Molecular Biology

Lost Without a Raft

E. M. Adler

Science Signaling (2011)

Review Oncology

Targeting protein prenylation for cancer therapy

Norbert Berndt et al.

NATURE REVIEWS CANCER (2011)

Review Biochemistry & Molecular Biology

Sterol metabolism and SREBP activation

Ryuichiro Sato

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)

Article Biochemistry & Molecular Biology

Association of fission proteins with mitochondrial raft-like domains

L. Ciarlo et al.

CELL DEATH AND DIFFERENTIATION (2010)

Article Cell Biology

Cholesterol, the central lipid of mammalian cells

Frederick R. Maxfield et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Katrin Duevel et al.

MOLECULAR CELL (2010)

Article Biochemistry & Molecular Biology

Lipid raft-targeted therapy in multiple myeloma

F. Mollinedo et al.

ONCOGENE (2010)

Article Multidisciplinary Sciences

Dysregulation of the mevalonate pathway promotes transformation

James W. Clendening et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis

S. Hani Najafi-Shoushtari et al.

SCIENCE (2010)

Article Pathology

Ezetimibe Is an Inhibitor of Tumor Angiogenesis

Keith R. Solomon et al.

AMERICAN JOURNAL OF PATHOLOGY (2009)

Review Endocrinology & Metabolism

Acyl-coenzyme A: cholesterol acyltransferases

Ta-Yuan Chang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)

Editorial Material Hematology

The LDL Receptor

Joseph L. Goldstein et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling

Aurelie Rossin et al.

BIOCHEMICAL JOURNAL (2009)

Article Biochemical Research Methods

Atomic Force Microscopy Imaging of Supramolecular Organization of Hyaluronan and Its Receptor CD44

Toshiyuki Murai et al.

IEEE TRANSACTIONS ON NANOBIOSCIENCE (2009)

Article Biochemistry & Molecular Biology

LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner

Aurelia Ouvrier et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Multidisciplinary Sciences

MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment

Sean P. Pitroda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Lipidation of apolipoprotein A-I by ATP-binding cassette transporter (ABC) A1 generates an interaction partner for ABCG1 but not for scavenger receptor BI

Iris Lorenzi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2008)

Article Cell Biology

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Thomas Porstmann et al.

CELL METABOLISM (2008)

Article Biochemistry & Molecular Biology

Regulation of cholesterologenesis by the oxysterol receptor, LXRα

Yongjun Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Oncology

The association between statins and cancer incidence in a veterans population

Wildon R. Farwell et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2008)

Review Cell Biology

Cellular cholesterol trafficking and compartmentalization

Elina Ikonen

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Article Multidisciplinary Sciences

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

Da-Wei Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Endocrinology & Metabolism

Do the cholesterol-lowering properties of statins affect cancer risk?

Keith R. Solomon et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2008)

Article Oncology

Differences in antitumor effects of various statins on human pancreatic cancer

Helena Gbelcova et al.

INTERNATIONAL JOURNAL OF CANCER (2008)

Article Biochemistry & Molecular Biology

Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols

Yoshio Yamauchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Activation of the hepatic LDL receptor promoter by thyroid hormone

Dayami Lopez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)

Article Biochemistry & Molecular Biology

Do mitochondria act as Cargo boats in the journey of GD3 to the nucleus during apoptosis?

Tina Garofaloa et al.

FEBS LETTERS (2007)

Article Biochemistry & Molecular Biology

Dynamics of lipid raft components during lymphocyte apoptosis: The paradigmatic role of GD3

Walter Malorni et al.

APOPTOSIS (2007)

Article Biochemistry & Molecular Biology

Palmitoylation is required for efficient Fas cell death signaling

Krittalak Chakrabandhu et al.

EMBO JOURNAL (2007)

Review Biochemistry & Molecular Biology

Use of cyclodextrins to manipulate plasma membrane cholesterol content: Evidence, misconceptions and control strategies

Raphael Zidovetzki et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)

Article Biochemistry & Molecular Biology

ATP-binding cassette transporter A1 expression disrupts raft membrane microdomains through its ATPase-related functions

Yves D. Landry et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Medicine, Research & Experimental

Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

LR Brunham et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Biochemistry & Molecular Biology

Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake

LQ Yu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Hematology

ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I

IC Gelissen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

Review Pharmacology & Pharmacy

Fas/CD95 death receptor and lipid rafts: New targets for apoptosis-directed cancer therapy

Faustino Mollinedo et al.

DRUG RESISTANCE UPDATES (2006)

Review Multidisciplinary Sciences

Role of cholesterol and lipid organization in disease

FR Maxfield et al.

NATURE (2005)

Article Biochemistry & Molecular Biology

Lipid microdomains contribute to apoptosis-associated modifications of mitochondria in T cells

T Garofalo et al.

CELL DEATH AND DIFFERENTIATION (2005)

Article Biochemistry & Molecular Biology

Control of ACAT2 liver expression by HNF1

C Pramfalk et al.

JOURNAL OF LIPID RESEARCH (2005)

Article Biochemistry & Molecular Biology

Identification and relevance of the CD95-binding domain in the N-terminal region of ezrin

F Lozupone et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption

SW Altmann et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Engagement of CD44 promotes Rac activation and CD44 cleavage during tumor cell migration

T Murai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Distinct endosomal compartments in early trafficking of low density lipoprotein-derived cholesterol

S Sugii et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Biochemistry & Molecular Biology

Lipid rafts: bringing order to chaos

LJ Pike

JOURNAL OF LIPID RESEARCH (2003)

Article Multidisciplinary Sciences

Structure of the LDL receptor extracellular domain at endosomal pH

G Rudenko et al.

SCIENCE (2002)

Review Multidisciplinary Sciences

Cell biology - How cells handle cholesterol

K Simons et al.

SCIENCE (2000)

Article Multidisciplinary Sciences

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα

A Venkateswaran et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Review Cell Biology

Lipid rafts and signal transduction

K Simons et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)

Review Biochemistry & Molecular Biology

Structure and function of sphingolipid- and cholesterol-rich membrane rafts

DA Brown et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)