相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Conformational rearrangement during activation of a metabotropic glutamate receptor
Brandon Wey-Hung Liauw et al.
NATURE CHEMICAL BIOLOGY (2021)
A versatile GPCR toolkit to track in vivo neuromodulation: not a one-size-fits-all sensor
Marie A. Labouesse et al.
NEUROPSYCHOPHARMACOLOGY (2021)
D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson's disease
Irene Sebastianutto et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
Nanobody-enabled monitoring of kappa opioid receptor states
Tao Che et al.
NATURE COMMUNICATIONS (2020)
β-Arrestin-2 BRET Biosensors Detect Different β-Arrestin-2 Conformations in Interaction with GPCRs
Atsuro Oishi et al.
ACS SENSORS (2020)
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
Reid H. J. Olsen et al.
NATURE CHEMICAL BIOLOGY (2020)
Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design
Marcin Maziarz et al.
CELL (2020)
Cryo-EM structures of inactive and active GABAB receptor
Chunyou Mao et al.
CELL RESEARCH (2020)
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
Kuglae Kim et al.
CELL (2020)
Structural basis of the activation of a metabotropic GABA receptor
Hamidreza Shaye et al.
NATURE (2020)
Structure of human GABA(B) receptor in an inactive state
Jinseo Park et al.
NATURE (2020)
Structures of metabotropic GABABreceptor
Makaia M. Papasergi-Scott et al.
NATURE (2020)
Structural insights into differences inGprotein activation by family Aand family BGPCRs
Daniel Hilger et al.
SCIENCE (2020)
FDA approves first BCMA-targeted therapeutic
Asher Mullard
NATURE REVIEWS DRUG DISCOVERY (2020)
Illuminating the allosteric modulation of the calcium-sensing receptor
Hongkang Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons
Wanling Peng et al.
SCIENCE (2020)
Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology
Chayma El Khamlichi et al.
MOLECULES (2019)
Structural insights into the activation of metabotropic glutamate receptors
Antoine Koehl et al.
NATURE (2019)
A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection
Shane C. Wright et al.
NATURE COMMUNICATIONS (2019)
Assembly of a GPCR-G Protein Complex
Yang Du et al.
CELL (2019)
To sense or not to sense-new insights from GPCR-based and arrestin-based biosensors
Raphael Silvanus Haider et al.
CURRENT OPINION IN CELL BIOLOGY (2019)
GPCR interaction as a possible way for allosteric control between receptors
Jean-Philippe Pin et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)
Illuminating G-Protein-Coupling Selectivity of GPCRs
Asuka Inoue et al.
CELL (2019)
Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer
Li Xue et al.
NATURE COMMUNICATIONS (2019)
Studying GPCR conformational dynamics by single molecule fluorescence
Robert B. Quast et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)
Genetic code expansion and photocross-linking identify different β-arrestin binding modes to the angiotensin II type 1 receptor
Laurence Gagnon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Beta-Arrestin1 Prevents Preeclampsia by Downregulation of Mechanosensitive AT1-B2 Receptor Heteromers
Ursula Quitterer et al.
CELL (2019)
Complex Formation between VEGFR2 and the β2-Adrenoceptor
Laura E. Kilpatrick et al.
CELL CHEMICAL BIOLOGY (2019)
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Tao Che et al.
CELL (2018)
A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice
Fangmiao Sun et al.
CELL (2018)
Pharmacogenomics of GPCR Drug Targets
Alexander S. Hauser et al.
CELL (2018)
Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells
Qingwen Wan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?
Krishna Sriram et al.
MOLECULAR PHARMACOLOGY (2018)
A FRET-based biosensor for measuring Gα13 activation in single cells
Marieke Mastop et al.
PLOS ONE (2018)
Intramolecular and Intermolecular FRET Sensors for GPCRs - Monitoring Conformational Changes and Beyond
Michael Kauk et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2018)
The Molecular Basis of G Protein-Coupled Receptor Activation
William I. Weis et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)
The Class-A GPCR Dopamine D2 Receptor Forms Transient Dimers Stabilized by Agonists: Detection by Single-Molecule Tracking
Rinshi S. Kasai et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2018)
A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics
Hannes Schihada et al.
COMMUNICATIONS BIOLOGY (2018)
Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes
Louis-Philippe Picard et al.
COMMUNICATIONS BIOLOGY (2018)
Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors
Rory Sleno et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context
Dominic Devost et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation
Pauline Scholler et al.
NATURE CHEMICAL BIOLOGY (2017)
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
Pauline Scholler et al.
NATURE COMMUNICATIONS (2017)
Distinct Conformational Dynamics of Three G Protein-Coupled Receptors Measured Using FlAsH-BRET Biosensors
Kyla Bourque et al.
FRONTIERS IN ENDOCRINOLOGY (2017)
Mini-G proteins: Novel tools for studying GPCRs in their active conformation
Rony Nehme et al.
PLOS ONE (2017)
FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABAB Receptor
Nathalie Lecat-Guillet et al.
CELL CHEMICAL BIOLOGY (2017)
NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells
Andrew S. Dixon et al.
ACS CHEMICAL BIOLOGY (2016)
G Protein-Coupled Receptor Heteromers
Ivone Gomes et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56 (2016)
Designing BRET-based conformational biosensors for G protein-coupled receptors
Rory Sleno et al.
METHODS (2016)
The conformational signature of β-arrestin2 predicts its trafficking and signalling functions
Mi-Hye Lee et al.
NATURE (2016)
β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle
Susanne Nuber et al.
NATURE (2016)
Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET
Yoon Namkung et al.
NATURE COMMUNICATIONS (2016)
Structural insights into μ-opioid receptor activation
Weijiao Huang et al.
NATURE (2015)
Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors
Ikuo Masuho et al.
SCIENCE SIGNALING (2015)
Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors
Ikuo Masuho et al.
SCIENCE SIGNALING (2015)
Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer
Li Xue et al.
NATURE CHEMICAL BIOLOGY (2015)
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Andrew C. Kruse et al.
NATURE (2013)
Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors
Etienne Doumazane et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate
Mary P. Hall et al.
ACS CHEMICAL BIOLOGY (2012)
Tools for GPCR drug discovery
Ru Zhang et al.
ACTA PHARMACOLOGICA SINICA (2012)
Allosteric interactions within the AT1 angiotensin receptor homodimer: Role of the conserved DRY motif
Bence Szalai et al.
BIOCHEMICAL PHARMACOLOGY (2012)
Deciphering biased-agonism complexity reveals a new active AT1 receptor entity
Aude Sauliere et al.
NATURE CHEMICAL BIOLOGY (2012)
Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2
Yong Geng et al.
NATURE NEUROSCIENCE (2012)
Sensitive and High Resolution Localization and Tracking of Membrane Proteins in Live Cells with BRET
Tien-Hung Lan et al.
TRAFFIC (2012)
Receptor-Heteromer Investigation Technology and its application using BRET
Elizabeth K. M. Johnstone et al.
Frontiers in Endocrinology (2012)
BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues
Martin Cottet et al.
Frontiers in Endocrinology (2012)
Fluorescence/Bioluminescence Resonance Energy Transfer Techniques to Study G-Protein-Coupled Receptor Activation and Signaling
Martin J. Lohse et al.
PHARMACOLOGICAL REVIEWS (2012)
Real-time visualization of heterotrimeric G protein Gq activation in living cells
Merel J. W. Adjobo-Hermans et al.
BMC BIOLOGY (2011)
The oligomeric state sets GABAB receptor signalling efficacy
Laetitia Comps-Agrar et al.
EMBO JOURNAL (2011)
A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors
Etienne Doumazane et al.
FASEB JOURNAL (2011)
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
Soren G. F. Rasmussen et al.
NATURE (2011)
Dimers and beyond: The functional puzzles of class C GPCRs
Julie Kniazeff et al.
PHARMACOLOGY & THERAPEUTICS (2011)
Interdomain movements in metabotropic glutamate receptor activation
Siluo Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Site-Specific, Orthogonal Labeling of Proteins in Intact Cells with Two Small Biarsenical Fluorophores
Alexander Zuern et al.
BIOCONJUGATE CHEMISTRY (2010)
Recent advances in bioluminescence resonance energy transfer technologies to study GPCR heteromerization
Mohammed A. Ayoub et al.
CURRENT OPINION IN PHARMACOLOGY (2010)
Differential Signaling of the Endogenous Agonists at the β2-Adrenergic Receptor
Susanne Reiner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Time-resolved FRET between GPCR ligands reveals oligomers in native tissues
Laura Albizu et al.
NATURE CHEMICAL BIOLOGY (2010)
Constitutive Dimerization of the G-Protein Coupled Receptor, Neurotensin Receptor 1, Reconstituted into Phospholipid Bilayers
Peter J. Harding et al.
BIOPHYSICAL JOURNAL (2009)
The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers
Bettye Hollins et al.
CELLULAR SIGNALLING (2009)
Optical measurement of mGluR1 conformational changes reveals fast activation, slow deactivation, and sensitization
Paikan Marcaggi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Functional complementation of high-efficiency resonance energy transfer: a new tool for the study of protein binding interactions in living cells
Paola Molinari et al.
BIOCHEMICAL JOURNAL (2008)
An engineered protein tag for multiprotein labeling in living cells
Arnaud Gautier et al.
CHEMISTRY & BIOLOGY (2008)
Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing δ-opioid receptors and heterotrimeric G proteins
Nicolas Audet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Agonist-selective, Receptor-specific Interaction of Human P2Y Receptors with β-Arrestin-1 and-2
Carsten Hoffmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization
Damien Maurel et al.
NATURE METHODS (2008)
Structural diversity of G protein-coupled receptors and significance for drug discovery
Malin C. Lagerstrom et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors
Arun K. Shukla et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Signaling through a G protein-coupled receptor and its corresponding G protein follows a stoichiometrically limited model
Finly Philip et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Takanori Muto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Real-time optical recording of beta(1)-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol
Francesca Rochais et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
GS activation is time-limiting in initiating receptor-mediated signaling
Peter Hein et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
G protein-coupled receptors sense fluid shear stress in endothelial cells
Mirianas Chachisvilis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Minimal determinants for binding activated Gα from the structure of a Gαi1-peptide dimer
Christopher A. Johnston et al.
BIOCHEMISTRY (2006)
Consensus guided mutagenesis of Renilla luciferase yields enhanced stability and light output
Andreas Markus Loening et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2006)
Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes
Celine Gales et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1α
M Tateyama et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells
M Nobles et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Dynamics of receptor/G protein coupling in living cells
P Hein et al.
EMBO JOURNAL (2005)
Functional assays for screening GPCR targets
W Thomsen et al.
CURRENT OPINION IN BIOTECHNOLOGY (2005)
Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase
J Yin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
High-throughput screening of G protein-coupled receptor antagonists using a bioluminescence resonance energy transfer 1-based β-arrestin2 recruitment assay
FF Hamdan et al.
JOURNAL OF BIOMOLECULAR SCREENING (2005)
G protein activation without subunit dissociation depends on a Gαi-specific region
M Frank et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Constitutive dimerization of human serotonin 5-HT4 receptors in living cells
M Berthouze et al.
FEBS LETTERS (2005)
Molecular basis of inverse agonism in a G protein-coupled receptor
JP Vilardaga et al.
NATURE CHEMICAL BIOLOGY (2005)
Methods to monitor the quaternary structure of G protein-coupled receptors
G Milligan et al.
FEBS JOURNAL (2005)
The repertoire of G-protein-coupled receptors in fully sequenced genomes
R Fredriksson et al.
MOLECULAR PHARMACOLOGY (2005)
Transduction of receptor signals by β-arrestins
RJ Leftowitz et al.
SCIENCE (2005)
Monitoring agonist-promoted conformational changes of β-arrestin in living cells by intramolecular BRET
PG Charest et al.
EMBO REPORTS (2005)
β-arrestin binding to the β2-adrenergic receptor requires both receptor phosphorylation and receptor activation
C Krasel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A FlAsH-based FRET approach to determine G protein -: coupled receptor activation in living cells
C Hoffmann et al.
NATURE METHODS (2005)
Real-time monitoring of receptor and G-protein interactions in living cells
C Galés et al.
NATURE METHODS (2005)
Heterodimerization of G protein-coupled receptors: Specificity and functional significance
SC Prinster et al.
PHARMACOLOGICAL REVIEWS (2005)
Real-time detection of interactions between the human oxytocin receptor and G protein-coupled receptor kinase-2
A Hasbi et al.
MOLECULAR ENDOCRINOLOGY (2004)
Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit
JF Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Closed state of both binding domains of homodimeric mGlu receptors is required for full activity
J Kniazeff et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers
MA Ayoub et al.
MOLECULAR PHARMACOLOGY (2004)
Specific labeling of cell surface proteins with chemically diverse compounds
N George et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
A fluorescence resonance energy transfer-based sensor indicates that receptor access to a G protein is unrestricted in a living mammalian cell
I Azpiazu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Gi protein activation in intact cells involves subunit rearrangement rather than dissociation
M Bünemann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins
JJ Carrillo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Palmitoylation of the V2 vasopressin receptor carboxyl tail enhances β-arrestin recruitment leading to efficient receptor endocytosis and ERK1/2 activation
PG Charest et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Measurement of the millisecond activation switch of G protein-coupled receptors in living cells
JP Vilardaga et al.
NATURE BIOTECHNOLOGY (2003)
The G-protein-coupled receptors in the human genome form five main families.: Phylogenetic analysis, paralogon groups, and fingerprints
R Fredriksson et al.
MOLECULAR PHARMACOLOGY (2003)
A general method for the covalent labeling of fusion proteins with small molecules in vivo
A Keppler et al.
NATURE BIOTECHNOLOGY (2003)
Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes -: Differential regulation of β-arrestins 1 and 2
AC Hanyaloglu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer
MA Ayoub et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Internalization determinants of the parathyroid hormone receptor differentially regulate β-arrestin/receptor association
JP Vilardaga et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+
D Tsuchiya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Functionally different agonists induce distinct conformations in the G protein coupling domain of the β2 adrenergic receptor
P Ghanouni et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Agonist-induced conformational changes in the G-protein-coupling domain of the β2 adrenergic receptor
P Ghanouni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor - Detection in living cells using bioluminescence resonance energy transfer
KM Kroeger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor
N Kunishima et al.
NATURE (2000)
Differential affinities of visual arrestin, βarrestin1, and βarrestin2 for G protein-coupled receptors delineate two major classes of receptors
RH Oakley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
分享论文
