A ride through the epigenetic landscape: aging reversal by reprogramming

Aging has become one of the fastest-growing research topics in biology. However, exactly how the aging process occurs remains unknown. Epigenetics plays a significant role, and several epigenetic interventions can modulate lifespan. This review will explore the interplay between epigenetics and aging, and how epigenetic reprogramming can be harnessed for age reversal. In vivo partial reprogramming holds great promise as a possible therapy, but several limitations remain. Rejuvenation by reprogramming is a young but rapidly expanding subfield in the biology of aging.

Automated summary

This review explores the interplay between epigenetics and aging, with a focus on the potential of epigenetic reprogramming for age reversal. While in vivo partial reprogramming holds promise as a therapy, there are several limitations that need to be addressed. Reprogramming for rejuvenation is a young but rapidly expanding subfield in the biology of aging.