期刊
PHARMACEUTICS
卷 13, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13040580
关键词
dry powder inhalation; compound excipient; force control agent; surface energy; adhesion strength
资金
- Land Schleswig-Holstein within the funding programme Open Access Publikationsfonds
The study compared two established dry particle coating options and found that using magnesium stearate can reduce surface energy of carrier particles and significantly enhance the aerodynamic performance of carrier-based blends. High-shear mixer coating offers significant benefits, including lower drug-carrier adhesion and higher efficiency in the coating process.
High-shear mixer coatings as well as mechanofusion processes are used in the particle-engineering of dry powder inhalation carrier systems. The aim of coating the carrier particle is usually to decrease carrier-drug adhesion. This study comprises the in-depth comparison of two established dry particle coating options. Both processes were conducted with and without a model additive (magnesium stearate). In doing so, changes in the behaviour of the processed particles can be traced back to either the process or the additive. It can be stated that the coarse model carrier showed no significant changes when processed without additives. By coating the particles with magnesium stearate, the surface energy decreased significantly. This leads to a significant enhancement of the aerodynamic performance of the respective carrier-based blends. Comparing the engineered carriers with each other, the high-shear mixer coating shows significant benefits, namely, lower drug-carrier adhesion and the higher efficiency of the coating process.
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