期刊
PHARMACEUTICS
卷 13, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13050625
关键词
biomimetic magnetic nanoparticles; combined tumor therapy; doxorubicine; HepG2 cancer cell line; MamC; magnetite nanoparticles; photothermia
资金
- Ministerio de Economia y Competitividad [CGL201676723, PID2019-109294RB-100]
- Ramon y Cajal program [RYC-2014-16901]
- Junta de Andalucia
- Programa Operativo FEDER [A1-FQM-341-UGR18, C-FQM-497-UGR18, A-BIO376-UGR18]
- Andalusian regional government [CTS-236]
- Ministerio de Ciencia, Innovacion y Universidades (Spain) [PRE2018-085440]
- Ministerio de Educacion, Ciencia y Deporte y Competitividad (Spain) [FPU16_04580]
The study shows that MamC-mediated BMNPs have the potential to increase temperature under near-infrared laser irradiation as a magnetic hyperthermia agent. Furthermore, the synergy between photothermia and chemotherapy using doxorubicin-functionalized BMNPs has shown effectiveness against tumor cells in vitro experiments.
MamC-mediated biomimetic magnetic nanoparticles (BMNPs) have emerged as one of the most promising nanomaterials due to their magnetic features (superparamagnetic character and large magnetic moment per particle), their novel surface properties determined by MamC, their biocompatibility and their ability as magnetic hyperthermia agents. However, the current clinical application of magnetic hyperthermia is limited due to the fact that, in order to be able to reach an effective temperature at the target site, relatively high nanoparticle concentration, as well as high magnetic field strength and/or AC frequency are needed. In the present study, the potential of BMNPs to increase the temperature upon irradiation of a laser beam in the near infrared, at a wavelength at which tissues become partially transparent, is explored. Moreover, our results also demonstrate the synergy between photothermia and chemotherapy in terms of drug release and cytotoxicity, by using BMNPs functionalized with doxorubicin, and the effectiveness of this combination therapy against tumor cells in in vitro experiments. Therefore, the findings of the present study open the possibility of a novel, alternative approach to fight localized tumors.
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