4.7 Review

Recent Advances in pH- or/and Photo-Responsive Nanovehicles

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Article Polymer Science

Control drug release behavior by highly stable and pH sensitive poly (N-vinylpyrrolidone)-block-poly(4-vinylpyridine) copolymer micelles

Avnish Kumar Mishra et al.

Summary: pH-sensitive and stable PNVP-b-P4VP micelles with low critical micelle concentration were successfully synthesized and showed excellent drug release capabilities under different pH conditions. The release of DOX could be effectively regulated by controlling pH, demonstrating high drug loading efficiency and good biocompatibility.

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Article Polymer Science

Light-Responsive Polymeric Micellar Nanoparticles with Enhanced Formulation Stability

Kyoung Nan Kim et al.

Summary: Light-sensitive polymeric micelles have been developed as promising drug delivery systems, with the ability to release drugs under UV light. The diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles show high stability and hydrophobicity.

POLYMERS (2021)

Article Materials Science, Multidisciplinary

Photothermal Therapy Based on CuS Nanoparticles for Alleviating Arterial Restenosis Induced by Mechanical Injury of Endovascular Treatment

Xiaoyu Wu et al.

Summary: CuS nanoparticles have shown potential in alleviating arterial inflammation in post-injury remodeling of the arterial wall. The study demonstrated efficient depletion of macrophages by CuS NPs, leading to alleviation of arterial stenosis.

FRONTIERS IN MATERIALS (2021)

Article Biophysics

ROP and ATRP fabricated redox sensitive micelles based on PCL-SS-PMAA diblock copolymers to co-deliver PTX and CDDP for lung cancer therapy

Yu-Lun Lo et al.

Summary: The study developed a pH/redox-responsive polymer micelle for dual drug delivery, showing that co-loading cisplatin and paclitaxel into the micelle had a synergistic effect in killing lung cancer cells, demonstrating superior antitumor activity compared to single drugs or equivalent drug combinations.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Chemistry, Medicinal

Development of programmable gemcitabine-GnRH pro-drugs bearing linker controllable click oxime bond tethers and preclinical evaluation against prostate cancer

Eirinaios Vrettos et al.

Summary: In this study, three peptide-drug conjugates were developed with gemcitabine as the cytotoxic unit and D-Lys6-GnRH as the cancer-targeting unit. These conjugates achieved selective targeting of malignant tumor cells through differential drug release rates guided by specific linkers.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Pharmacology & Pharmacy

Release of the model drug SR101 from polyurethane nanocapsules in porcine hair follicles triggered by LED-derived low dose UVA light

Loris Busch et al.

Summary: The study introduces a novel preclinical model for targeted intrafollicular drug release, utilizing UVA-responsive nanocapsules for fluorescence-labeled drug release and investigating follicular penetration through microscopy. The system demonstrates considerable and controllable release of various water-soluble therapeutics without risking tissue damage, showing promising potential for clinical applications such as preoperative antisepsis of hair follicles.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

Hyaluronic Acid-Functionalized Hollow Mesoporous Silica Nanoparticles as pH-Sensitive Nanocarriers for Cancer Chemo-Photodynamic Therapy

Yimin Zhou et al.

Summary: The study successfully developed ID@HMSNs-B-HA nanoparticles for targeted drug delivery, showing sustained drug release under acidic conditions with effective inhibition of murine mammary carcinoma (4T1) cells through combined chemotherapy and photodynamic therapy. The results indicated that ID@HMSNs-B-HA could be a promising nano-DDS for cancer treatment.

LANGMUIR (2021)

Article Chemistry, Multidisciplinary

Light-Activated Hypoxia-Sensitive Covalent Organic Framework for Tandem-Responsive Drug Delivery

Lei Ge et al.

Summary: COFs have been synthesized with hypoxia-responsive azo bonds containing photosensitizers and hypoxia-activated drugs for drug delivery. Upon exposure to hypoxic conditions and NIR light, the COF structure is disrupted, leading to drug release and activation of the hypoxia-activated drug, resulting in effective cancer cell killing and tumor growth inhibition.

NANO LETTERS (2021)

Review Pharmacology & Pharmacy

Physical properties of nanoparticles do matter

Tony Mutiso Kiio et al.

Summary: This article highlights the importance of the physical properties of nanoparticles (NPs) in determining pharmaceutical functions, including their size, shape, surface charge, and elasticity. Research has shown that optimizing these properties can enhance cellular uptake, reduce immunogenicity, and improve tumor accumulation, ultimately impacting the pharmacokinetic properties of drug delivery systems.

JOURNAL OF PHARMACEUTICAL INVESTIGATION (2021)

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Graphene-based nanomaterial system: a boon in the era of smart nanocarriers

Roopali Jha et al.

Summary: Graphene, with its exceptional characteristics, has opened up novel innovative opportunities for future devices and nanosystems. It is particularly promising as a drug delivery carrier and has vast potential in various fields. However, further research and development are needed before its full potential can be realized.

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Silver nanoparticle-embedded hydrogel as a photothermal platform for combating bacterial infections

Yingnan Liu et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Facile Fabrication Route of Janus Gold-Mesoporous Silica Nanocarriers with Dual-Drug Delivery for Tumor Therapy

Yang Xing et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

Article Materials Science, Biomaterials

Light-, temperature-, and pH-responsive micellar assemblies of spiropyran-initiated amphiphilic block copolymers: Kinetics of photochromism, responsiveness, and smart drug delivery

Bahareh Razavi et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Chemistry, Physical

Mesoporous platinum nanoparticle-based nanoplatforms for combined chemo-photothermal breast cancer therapy

Bei Fu et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2020)

Review Biochemistry & Molecular Biology

Photo-Based Nanomedicines Using Polymeric Systems in the Field of Cancer Imaging and Therapy

Patihul Husni et al.

BIOMEDICINES (2020)

Review Pharmacology & Pharmacy

Recent developments in cancer therapy and diagnosis

Evren Atlihan-Gundogdu et al.

JOURNAL OF PHARMACEUTICAL INVESTIGATION (2020)

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Photo-Triggered Delivery of siRNA and Paclitaxel into Breast Cancer Cells Using Catanionic Vesicles

Zumra Peksaglam Seidel et al.

ACS APPLIED BIO MATERIALS (2020)

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Recent advances of nanotechnology for the delivery of anticancer drugs for breast cancer treatment

Phuong Tran et al.

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A nano-complex system to overcome antagonistic photo-chemo combination cancer therapy

Chaemin Lim et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Article Biotechnology & Applied Microbiology

Polymers, responsiveness and cancer therapy

Anil M. Pethe et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

Article Chemistry, Applied

BSA modified, disulfide-bridged mesoporous silica with low biotoxicity for dual-responsive drug delivery

Junna Lu et al.

MICROPOROUS AND MESOPOROUS MATERIALS (2019)

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Gold Nanoparticles for Photothermal Cancer Therapy

Jeremy B. Vines et al.

FRONTIERS IN CHEMISTRY (2019)

Article Materials Science, Biomaterials

Development of biotin molecule targeted cancer cell drug delivery of doxorubicin loaded κ-carrageenan grafted graphene oxide nanocarrier

Kandasamy Vinothini et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Article Biotechnology & Applied Microbiology

Dual pH-sensitive liposomes with low pH-triggered sheddable PEG for enhanced tumor-targeted drug delivery

Manju Kanamala et al.

NANOMEDICINE (2019)

Article Chemistry, Physical

pH-responsive dithiomaleimide-amphiphilic block copolymer for drug delivery and cellular imaging

Ting Bai et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

Article Materials Science, Biomaterials

PEGylated graphene oxide-capped gold nanorods/silica nanoparticles as multifunctional drug delivery platform with enhanced near-infrared responsiveness

Zeer Qi et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Review Chemistry, Multidisciplinary

Nanocarriers for drug delivery applications

Munusamy Chamundeeswari et al.

ENVIRONMENTAL CHEMISTRY LETTERS (2019)

Review Polymer Science

Light-Switchable Azobenzene-Containing Macromolecules: From UV to Near Infrared

Philipp Weis et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2018)

Article Nanoscience & Nanotechnology

Light-Induced Hypoxia-Triggered Living Nanocarriers for Synergistic Cancer Therapy

Wenliang Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Review Medicine, Research & Experimental

Nanotherapeutics: An insight into healthcare and multi-dimensional applications in medical sector of the modern world

Minakshi Prasad et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Medicine, Research & Experimental

Photodynamic therapy - mechanisms, photosensitizers and combinations

Stanislaw Kwiatkowski et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Biophysics

Biodegradable, pH-sensitive chitosan beads obtained under microwave radiation for advanced cell culture

Marek Piatkowski et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

Article Biochemistry & Molecular Biology

Synthesis and evaluation on pH-and temperature-responsive chitosan-p(MAA-co-NIPAM) hydrogels

S. Z. M. Rasib et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Article Materials Science, Biomaterials

Delivery of anticancer drug using pH-sensitive micelles from triblock copolymer MPEG-b-PBAE-b-PLA

Chufen Yang et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

Review Multidisciplinary Sciences

Progress and challenges towards targeted delivery of cancer therapeutics

Daniel Rosenblum et al.

NATURE COMMUNICATIONS (2018)

Article Materials Science, Biomaterials

A sequential enzyme-activated and light-triggered pro-prodrug nanosystem for cancer detection and therapy

Zelin Chen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

Review Radiology, Nuclear Medicine & Medical Imaging

Imaging Nanomedicine-Based Drug Delivery: a Review of Clinical Studies

Francis Man et al.

MOLECULAR IMAGING AND BIOLOGY (2018)

Article Materials Science, Biomaterials

Near-Infrared Light-Triggered Hydrophobic-to-Hydrophilic Switch Nanovalve for On-Demand Cancer Therapy

Ren-Lu Han et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

Article Nanoscience & Nanotechnology

A Route to Triggered Delivery via Photocontrol of Lipid Bilayer Properties Using Lanthanide Upconversion Nanoparticles

Paola A. Rojas-Gutierrez et al.

ACS APPLIED NANO MATERIALS (2018)

Review Chemistry, Multidisciplinary

Hydrogels based on pH-responsive reversible carbon-nitrogen double-bond linkages for biomedical applications

Zhen Zhang et al.

MATERIALS CHEMISTRY FRONTIERS (2018)

Review Chemistry, Multidisciplinary

Reactive-Oxygen-Species-Responsive Drug Delivery Systems: Promises and Challenges

Gurusamy Saravanakumar et al.

ADVANCED SCIENCE (2017)

Article Chemistry, Physical

Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy

Yang Yang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2017)

Article Nanoscience & Nanotechnology

Prussian blue nanoparticle-based photothermal therapy combined with checkpoint inhibition for photothermal immunotherapy of neuroblastoma

Juliana Cano-Mejia et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

Article Materials Science, Biomaterials

Biocompatible CuS-based nanoplatforms for efficient photothermal therapy and chemotherapy in vivo

Shuwen Peng et al.

BIOMATERIALS SCIENCE (2017)

Article Materials Science, Biomaterials

pH and redox dual-sensitive polysaccharide nanoparticles for the efficient delivery of doxorubicin

Shengcai Yang et al.

BIOMATERIALS SCIENCE (2017)

Article Materials Science, Biomaterials

Doxorubicin-Loaded Photosensitizer-Core pH-Responsive Copolymer Nanocarriers for Combining Photodynamic Therapy and Chemotherapy

Xiaohan Zhang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

Article Materials Science, Biomaterials

Doxorubicin-Loaded Photosensitizer-Core pH-Responsive Copolymer Nanocarriers for Combining Photodynamic Therapy and Chemotherapy

Xiaohan Zhang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

Article Nanoscience & Nanotechnology

Near-Infrared Light Responsive Folate Targeted Gold Nanorods for Combined Photothermal-Chemotherapy of Osteosarcoma

Anna Li Volsi et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Article Chemistry, Multidisciplinary

Carbon Dot Nanothermometry: Intracellular Photoluminescence Lifetime Thermal Sensing

Sergii Kalytchuk et al.

ACS NANO (2017)

Article Nanoscience & Nanotechnology

Near-Infrared Organic Dye-Based Nanoagent for the Photothermal Therapy of Cancer

Bingjiang Zhou et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Article Chemistry, Multidisciplinary

Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy

Chenggen Qian et al.

ADVANCED MATERIALS (2016)

Review Chemistry, Multidisciplinary

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Mahdi Karimi et al.

CHEMICAL SOCIETY REVIEWS (2016)

Article Biophysics

pH-responsive targeted and controlled doxorubicin delivery using hyaluronic acid nanocarriers

Deepanjali D. Gurav et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

Article Pharmacology & Pharmacy

Dual-pH responsive micelle platform for co-delivery of axitinib and doxorubicin

Xiuli Xu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

Article Materials Science, Biomaterials

Construction of coumarin-based cross-linked micelles with pH responsive hydrazone bond and tumor targeting moiety

Yu-Bo Long et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

Article Chemistry, Multidisciplinary

Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles

Shuqing He et al.

CHEMICAL COMMUNICATIONS (2015)

Review Chemistry, Multidisciplinary

Multi-Stimuli-Responsive Polymeric Materials

Sudhina Guragain et al.

CHEMISTRY-A EUROPEAN JOURNAL (2015)

Article Nanoscience & Nanotechnology

PEGylated Dendrimer-Doxorubicin Cojugates as pH-Sensitive Drug Delivery Systems: Synthesis and In Vitro Characterization

Wenchuan She et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2015)

Article Multidisciplinary Sciences

Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes

Alina Y. Rwei et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Chemistry, Physical

Recent advances in the development of organic photothermal nano-agents

Xuejiao Song et al.

NANO RESEARCH (2015)

Article Chemistry, Multidisciplinary

Stimuli-Responsive Theragrippers for Chemomechanical Controlled Release

Kate Malachowski et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Review Biotechnology & Applied Microbiology

pH-Sensitive nano-systems for drug delivery in cancer therapy

Juan Liu et al.

BIOTECHNOLOGY ADVANCES (2014)

Article Chemistry, Multidisciplinary

Oxime Ligation: A Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs

Sebastien Ulrich et al.

CHEMISTRY-A EUROPEAN JOURNAL (2014)

Review Chemistry, Multidisciplinary

Graphene-based nanomaterials for drug delivery and tissue engineering

Sumit Goenka et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Review Chemistry, Multidisciplinary

Novel pH-Sensitive Biodegradable Polymeric Drug Delivery Systems Based on Ketal Polymers

Daquan Chen et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2014)

Review Polymer Science

Multi-stimuli responsive polymers - the all-in-one talents

Philipp Schattling et al.

POLYMER CHEMISTRY (2014)

Article Nanoscience & Nanotechnology

Targeted Delivery System Based on Magnetic Mesoporous Silica Nanocomposites with Light-Controlled Release Character

Yanyan Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2013)

Review Engineering, Biomedical

Graphene and graphene oxide as new nanocarriers for drug delivery applications

Jingquan Liu et al.

ACTA BIOMATERIALIA (2013)

Article Chemistry, Multidisciplinary

Low Power Upconverted Near-IR Light for Efficient Polymeric Nanoparticle Degradation and Cargo Release

Mathieu L. Viger et al.

ADVANCED MATERIALS (2013)

Review Chemistry, Physical

Stimuli-responsive nanocarriers for drug delivery

Simona Mura et al.

NATURE MATERIALS (2013)

Review Pharmacology & Pharmacy

pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates

Arnaud E. Felber et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Review Pharmacology & Pharmacy

Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications

Emanuel Fleige et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Article Chemistry, Physical

Near-infrared light sensitive polypeptide block copolymer micelles for drug delivery

Surjith Kumar et al.

JOURNAL OF MATERIALS CHEMISTRY (2012)

Article Chemistry, Multidisciplinary

Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

Rong Tong et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Review Chemistry, Multidisciplinary

Strategies for the intracellular delivery of nanoparticles

Leo Y. T. Chou et al.

CHEMICAL SOCIETY REVIEWS (2011)

Article Chemistry, Multidisciplinary

Light- and pH-Responsive Release of Doxorubicin from a Mesoporous Silica-Based Nanocarrier

Nikola Z. Knezevic et al.

CHEMISTRY-A EUROPEAN JOURNAL (2011)

Article Chemistry, Multidisciplinary

Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery

Jin-Zhi Du et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Review Oncology

Cancer research: past, present and future

Ya Cao et al.

NATURE REVIEWS CANCER (2011)

Review Pharmacology & Pharmacy

Liposomal cancer therapy: exploiting tumor characteristics

Thomas Kaasgaard et al.

EXPERT OPINION ON DRUG DELIVERY (2010)

Article Biochemistry & Molecular Biology

N-Boc-Histidine-Capped PLGA-PEG-PLGA as a Smart Polymer for Drug Delivery Sensitive to Tumor Extracellular pH

Guangtao Chang et al.

MACROMOLECULAR BIOSCIENCE (2010)

Review Pharmacology & Pharmacy

Multifunctional and stimuli-sensitive pharmaceutical nanocarriers

Vladimir Torchilin

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2009)

Review Pharmacology & Pharmacy

Nanoparticles in photodynamic therapy: An emerging paradigm

Dev Kumar Chatterjee et al.

ADVANCED DRUG DELIVERY REVIEWS (2008)

Article Chemistry, Multidisciplinary

Hydrolytic stability of hydrazones and oximes

Jeet Kalia et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

Article Biochemistry & Molecular Biology

pH-triggered reversible stealth polycationic micelles

Jingxia Gu et al.

BIOMACROMOLECULES (2008)

Article Chemistry, Physical

Femtosecond midinfrared study of the photoinduced Wolff rearrangement of diazonaphthoquinone

Daniel Wolpert et al.

JOURNAL OF CHEMICAL PHYSICS (2008)

Article Chemistry, Multidisciplinary

Tumor pH-responsive flower-like micelles of poly(L-lactic acid)-b-poly (ethylene glycol)-b-poly(L-histidine)

Eun Seong Lee et al.

JOURNAL OF CONTROLLED RELEASE (2007)

Article Chemistry, Multidisciplinary

Histidine-conjugated poly(amino acid) derivatives for the novel endosomolytic delivery carrier of doxorubicin

Seung Rim Yang et al.

JOURNAL OF CONTROLLED RELEASE (2006)

Article Biochemical Research Methods

Polyketal nanoparticles: A new pH-sensitive biodegradable drug delivery vehicle

MJ Heffernan et al.

BIOCONJUGATE CHEMISTRY (2005)

Article Multidisciplinary Sciences

Drug delivery systems: Entering the mainstream

TM Allen et al.

SCIENCE (2004)

Article Biochemical Research Methods

Acetals as pH-sensitive linkages for drug delivery

ER Gillies et al.

BIOCONJUGATE CHEMISTRY (2004)

Article Biotechnology & Applied Microbiology

Investing in nanotechnology

R Paull et al.

NATURE BIOTECHNOLOGY (2003)

Article Chemistry, Multidisciplinary

Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization

ES Lee et al.

JOURNAL OF CONTROLLED RELEASE (2003)

Article Chemistry, Physical

Aconityl-derived polymers for biomedical applications. Modeling study of cis-trans isomerisation

M Zloh et al.

THEORETICAL CHEMISTRY ACCOUNTS (2003)