Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma

Glioblastoma (GBM) is among the most aggressive of brain tumors and confers a dismal prognosis despite advances in surgical technique, radiation delivery methods, chemotherapy, and tumor-treating fields. While immunotherapy (IT) has improved the care of several adult cancers with previously dismal prognoses, monotherapy with IT in GBM has shown minimal response in first recurrence. Recent discoveries in lymphatics and evaluation of blood brain barrier offer insight to improve the use of ITs and determine the best combinations of therapies, including radiation. We highlight important features of the tumor immune microenvironment in GBM and potential for combining radiation and immunotherapy to improve prognosis in this devastating disease.

Automated summary

Glioblastoma (GBM) is a highly aggressive brain tumor with poor prognosis. Immunotherapy has shown limited response as monotherapy in GBM, despite advances in the field. Recent discoveries offer insight into improving immunotherapy and exploring combinations with treatments like radiation to enhance prognosis in this devastating disease.