4.6 Article

Multi-Omics Analysis of Brain Metastasis Outcomes Following Craniotomy

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FRONTIERS IN ONCOLOGY
卷 10, 期 -, 页码 -

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FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2020.615472

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bioinformatics analysis; brain metastases; craniotomy; distant brain failure; RNA-Seq; RNA sequencing; proteomics; metabolomics; non-negative matrix factorization

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资金

  1. National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR001420]
  2. Indiana University Precision Health Initiative

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This study used a multi-omics approach to characterize brain metastasis and identified two molecular subtypes with significantly different prognoses, revealing key pathways and metabolites. The results indicated that the immune microenvironment landscape and proliferation and migration signaling pathways may contribute to the observed survival differences, providing an opportunity to identify clinically impactful biomarkers.
Background The incidence of brain metastasis continues to increase as therapeutic strategies have improved for a number of solid tumors. The presence of brain metastasis is associated with worse prognosis but it is unclear if distinctive biomarkers can separate patients at risk for CNS related death. Methods We executed a single institution retrospective collection of brain metastasis from patients who were diagnosed with lung, breast, and other primary tumors. The brain metastatic samples were sent for RNA sequencing, proteomic and metabolomic analysis of brain metastasis. The primary outcome was distant brain failure after definitive therapies that included craniotomy resection and radiation to surgical bed. Novel prognostic subtypes were discovered using transcriptomic data and sparse non-negative matrix factorization. Results We discovered two molecular subtypes showing statistically significant differential prognosis irrespective of tumor subtype. The median survival time of the good and the poor prognostic subtypes were 7.89 and 42.27 months, respectively. Further integrated characterization and analysis of these two distinctive prognostic subtypes using transcriptomic, proteomic, and metabolomic molecular profiles of patients identified key pathways and metabolites. The analysis suggested that immune microenvironment landscape as well as proliferation and migration signaling pathways may be responsible to the observed survival difference. Conclusion A multi-omics approach to characterization of brain metastasis provides an opportunity to identify clinically impactful biomarkers and associated prognostic subtypes and generate provocative integrative understanding of disease.

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