期刊
FRONTIERS IN ONCOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.619915
关键词
lncRNA LINC00152; KLF5; breast cancer; positive feedback loop; cell proliferation
类别
资金
- National Natural Science Foundation of China [82003236, 81802626, 81972854, 82003215]
- Zhejiang Provincial Nature Science Foundation of China [LQ20H160030, LQ20H160063]
- Zhejiang Provincial People's Hospital Scientific Research Returned Foundation for the Excellent Youth [ZRY2018C009, ZRY2018B002]
- Shanghai Jiao Tong University Medical Engineering Cross Fund [YG2017QN49]
- Nurturing Fund of Renji Hospital [PYZY16-018]
The study revealed that LINC00152 is significantly upregulated in breast cancer, serving as an indicator of poor prognosis. Knockdown of LINC00152 suppresses cell proliferation and tumorigenicity, and its interaction with KLF5 promotes tumor progression.
The long noncoding RNA (lncRNA) LINC00152, also known as CYTOR, displays aberrant expression in various cancers. However, its clinical value and functional mechanisms in breast cancer remain insufficiently understood. Our study found that LINC00152 is significantly upregulated in breast cancer, and that it acts as an indicator of poor survival prognosis. Further studies revealed that LINC00152 knockdown suppresses cell proliferation and tumorigenicity in vitro and in vivo. Mechanistic analyses demonstrated that LINC00152 directly binds to KLF5 protein and increases KLF5 stability. Moreover, LINC00152 is also a KLF5-responsive lncRNA, and KLF5 activates LINC00152 transcription by directly binding to its promoter. Our study suggests that LINC00152 promotes tumor progression by interacting with KLF5. LINC00152 may be a valuable prognostic predictor for breast cancer, and the positive feedback loop of LINC00152-KLF5 could be a therapeutic target in pharmacological strategies.
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