期刊
FRONTIERS IN ONCOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.653037
关键词
tumor microenvironment; DNA methylation; histone methyltransferases; histone deacetylases; microRNAs; hepatic stellate cells; tumor-associated macrophages; extracellular matrix
类别
资金
- American Cancer Society [RSG-18-107]
- National Cancer Institute [R01CA197128]
This article summarizes the current understanding of epigenetic regulation in the HCC microenvironment and reviews recent studies on the role of specific epigenetic mechanisms in HCC development.
Hepatocellular carcinoma (HCC) is a highly lethal and complex malignancy strongly influenced by the surrounding tumor microenvironment. The HCC microenvironment comprises hepatic stellate cells (HSCs), tumor-associated macrophages (TAMs), stromal and endothelial cells, and the underlying extracellular matrix (ECM). Emerging evidence demonstrates that epigenetic regulation plays a crucial role in altering numerous components of the HCC tumor microenvironment. In this review, we summarize the current understanding of the mechanisms of epigenetic regulation of the microenvironment in HCC. We review recent studies demonstrating how specific epigenetic mechanisms (DNA methylation, histone regulation, and non-coding RNAs mediated regulation) in HSCs, TAMs, and ECM, and how they contribute to HCC development, so as to gain new insights into the treatment of HCC via regulating epigenetic regulation in the tumor microenvironment.
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