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Strategies for the Construction of Mouse Models With Humanized Immune System and Evaluation of Tumor Immune Checkpoint Inhibitor Therapy

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FRONTIERS IN ONCOLOGY
卷 11, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.673199

关键词

humanized immune system; mouse model; tumor; immunotherapy; combination therapy

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资金

  1. National Natural Science Foundation Program of China [31772546, 32070532]
  2. Shaanxi Natural Science Foundation Program [2020PT-005]

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This article summarizes strategies for the development and use of HIS mice models in tumor immunotherapies, proposes a method of tumor identification and classification in HIS mice based on the tumor-infiltrating lymphocytes and PD-L1 expression, and suggests different combination treatment strategies to enhance the effect of immunotherapy.
Immunotherapy has been used as a first-line treatment for a variety of advanced tumors, allowing remarkable progress to be made in cancer treatment. Nonetheless, only a small number of patients can benefit from immune checkpoint inhibitor monotherapy. To improve the effect of immunotherapy, the underlying mechanism of combination therapy was investigated in the context of an intact human tumor immune microenvironment using mice with a human immune system (HIS) bearing human tumors. Herein, we summarize and discuss strategies for the development and use of HIS mice models in tumor immunotherapies. Most importantly, this review proposes a method of t11umor identification and classification in HIS mice based on the tumor-infiltrating lymphocytes and PD-L1 expression, and according to this classification, we propose different combination treatment strategies that can be utilized to enhance the effect of immunotherapy. Thus, we provide effective experimental schemes for tumor immunotherapy in HIS mice models.

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