期刊
FRONTIERS IN ONCOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.643620
关键词
lymphoma; cytoskeleton; signaling cascades; shape regulation; cytokinesis
类别
资金
- Ministero della Salute (Ricerca Finalizzata) [GR-2016-02364298]
Defects in cytoskeleton functions play a crucial role in tumorigenesis by promoting aberrant proliferation, migratory behavior, and invasive features. Research has shown significant alterations targeting the cytoskeleton in peripheral T cell lymphomas (PTCL), indicating its importance in malignant cell division. Aberrant signaling pathways such as JAK/STAT3, NPM-ALK, RhoGTPase, and Aurora Kinase also contribute to lymphomagenesis by modifying the structure and signaling properties of the cytoskeleton.
Defects in cytoskeleton functions support tumorigenesis fostering an aberrant proliferation and promoting inappropriate migratory and invasive features. The link between cytoskeleton and tumor features has been extensively investigated in solid tumors. However, the emerging genetic and molecular landscape of peripheral T cell lymphomas (PTCL) has unveiled several alterations targeting structure and function of the cytoskeleton, highlighting its role in cell shape changes and the aberrant cell division of malignant T cells. In this review, we summarize the most recent evidence about the role of cytoskeleton in PTCLs development and progression. We also discuss how aberrant signaling pathways, like JAK/STAT3, NPM-ALK, RhoGTPase, and Aurora Kinase, can contribute to lymphomagenesis by modifying the structure and the signaling properties of cytoskeleton.
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