期刊
FRONTIERS IN ONCOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.660712
关键词
curcumin; cancer; ncRNA; miRNA; signaling pathway; review
类别
资金
- National Natural Science Foundation of China [U1904133,81903688]
- Program for Young Key Teachers in Colleges and Universities in Henan Province [2020GGJS150]
- Natural Science Foundation of Henan Province of China [212300410224]
- Scientific Research Foundation of Xinxiang Medical University [XYBSKYZZ201512]
- National Training Programs of Innovation and Entrepreneurship for Undergraduates [202010472011]
Curcumin, a natural polyphenol derived from turmeric, demonstrates anti-inflammatory, antioxidant, and especially anti-tumor activities through multiple biological signaling pathways. Additionally, it inhibits tumor proliferation, angiogenesis, EMT, invasion, and metastasis by regulating tumor-related ncRNA expression. The cross regulatory relationship between ncRNA and signaling pathways illustrates the anti-tumor mechanism of curcumin.
Curcumin [(1E,6E) -1,7-bis(4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5- dione] is a natural polyphenol derived from the rhizome of the turmeric plant Curcuma longa. Accumulated evidences have presented curcumin's function in terms of anti-inflammatory, antioxidant properties, and especially anti-tumor activities. Studies demonstrated that curcumin could exert anti-tumor activity via multiple biological signaling pathways, such as PI3K/Akt, JAK/STAT, MAPK, Wnt/beta-catenin, p53, NF-B and apoptosis related signaling pathways. Moreover, Curcumin can inhibit tumor proliferation, angiogenesis, epithelial-mesenchymal transition (EMT), invasion and metastasis by regulating tumor related non-coding RNA (ncRNA) expression. In this review, we summarized the roles of curcumin in regulating signaling pathways and ncRNAs in different kinds of cancers. We also discussed the regulatory effect of curcumin through inhibiting carcinogenic miRNA and up regulating tumor suppressive miRNA. Furthermore, we aim to illustrate the cross regulatory relationship between ncRNA and signaling pathways, further to get a better understanding of the anti-tumor mechanism of curcumin, thus lay a theoretical foundation for the clinical application of curcumin in the future.
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