4.7 Article

Phase separation of EML4-ALK in firing downstream signaling and promoting lung tumorigenesis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

Asmin Tulpule et al.

Summary: A membraneless, protein granule-based subcellular structure has been identified to organize RTK/RAS/MAPK signaling in cancer cells, actively signaling within the cytoplasm and activating RAS independently of lipid membranes. The formation of RTK protein granules is critical for oncogenic RAS/MAPK signaling output in these cells. This study reveals a distinct subcellular platform for organizing oncogenic RTK and RAS signaling through higher-order cytoplasmic protein assembly.
Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Cell Biology

ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions

Qianting Zhang et al.

NATURE CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer

Ying Zhang et al.

MOLECULAR CANCER (2018)

Review Cell Biology

Protein Phase Separation: A New Phase in Cell Biology

Steven Boeynaems et al.

TRENDS IN CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

Jill J. Bouchard et al.

MOLECULAR CELL (2018)

Article Biochemistry & Molecular Biology

Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain

Gaylor Boulay et al.

Review Oncology

The role of the ALK receptor in cancer biology

B. Hallberg et al.

ANNALS OF ONCOLOGY (2016)

Review Cell Biology

Phase separation in biology; functional organization of a higher order

Diana M. Mitrea et al.

CELL COMMUNICATION AND SIGNALING (2016)

Article Biochemistry & Molecular Biology

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

Chi W. Pak et al.

MOLECULAR CELL (2016)

Article Biochemistry & Molecular Biology

Phase Transition of Spindle-Associated Protein Regulate Spindle Apparatus Assembly

Hao Jiang et al.

Review Cell Biology

Liquid-Liquid Phase Separation in Biology

Anthony A. Hyman et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

Article Biochemistry & Molecular Biology

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

Dong Gao et al.

Article Multidisciplinary Sciences

LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling

Yijun Gao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Oncology

Inhibition of ALK Signaling for Cancer Therapy

Yael P. Mosse et al.

CLINICAL CANCER RESEARCH (2009)

Editorial Material Oncology

EML4-ALK: Honing In on a New Target in Non-Small-Cell Lung Cancer

Leora Horn et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

Article Oncology

EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer

Jussi P. Koivunen et al.

CLINICAL CANCER RESEARCH (2008)

Article Multidisciplinary Sciences

Somatic mutations affect key pathways in lung adenocarcinoma

Li Ding et al.

NATURE (2008)

Article Multidisciplinary Sciences

A mouse model for EML4-ALK-positive lung cancer

Manabu Soda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

LKB1 modulates lung cancer differentiation and metastasis

Hongbin Ji et al.

NATURE (2007)

Article Developmental Biology

Characterization of the expression of the ALK receptor tyrosine kinase in mice

E Vernersson et al.

GENE EXPRESSION PATTERNS (2006)

Article Biochemistry & Molecular Biology

The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus

B Eichenmüller et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)