期刊
CELL DISCOVERY
卷 7, 期 1, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41421-021-00250-9
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资金
- Science & Technology Commission of Chongqing [cstc2020jscx-fyzx0053, cstc2018jcyjAX0027, cstc2018jscx-msybX0376]
- Chongqing Municipal Education Commission [KJQN201800422]
- Emergency Project for Novel Coronavirus Pneumonia from the Chongqing Medical University [CQMUNCP0301, CQMUNCP0304]
- Venture and Innovation Support Program for Chongqing Overseas Returnees [Cx2019070]
- National Key RD Project [2018YFE0107500]
- Chongqing Talents Program
This study evaluated the durability of protective immune responses in individuals recovered from asymptomatic or symptomatic SARS-CoV-2 infection approximately 6 months prior. Memory B cell response specific to the RBD of SARS-CoV-2 was relatively low, while T cell responses were observed in individuals recovered from COVID-19, and cross-reactive T cell responses were detected in healthy controls.
It is important to evaluate the durability of the protective immune response elicited by primary infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we systematically evaluated the SARS-CoV-2-specific memory B cell and T cell responses in healthy controls and individuals recovered from asymptomatic or symptomatic infection approximately 6 months prior. Comparatively low frequencies of memory B cells specific for the receptor-binding domain (RBD) of spike glycoprotein (S) persisted in the peripheral blood of individuals who recovered from infection (median 0.62%, interquartile range 0.48-0.69). The SARS-CoV-2 RBD-specific memory B cell response was detected in 2 of 13 individuals who recovered from asymptomatic infection and 10 of 20 individuals who recovered from symptomatic infection. T cell responses induced by S, membrane (M), and nucleocapsid (N) peptide libraries from SARS-CoV-2 were observed in individuals recovered from coronavirus disease 2019 (COVID-19), and cross-reactive T cell responses to SARS-CoV-2 were also detected in healthy controls.
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