期刊
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 17, 期 1, 页码 4-19出版社
SHENYANG PHARMACEUTICAL UNIV
DOI: 10.1016/j.ajps.2021.03.003
关键词
MSCs transplantation; Spinal cord injury; Biomaterials; Functional regeneration
资金
- National Key Research and Development Project of Stem Cell and Transformation Research [2019YFA0112100, 2019YFA0112102]
- National Natural Science Foundation of China [81973252, 81620108028]
Due to the complex pathophysiological mechanism, spinal cord injury (SCI) is difficult to treat using traditional cell transplantation strategies. However, the use of biomaterials to enhance MSCs transplantation has gained attention in recent years. Biomaterials can improve cell survival rate and enhance therapeutic effects.
Due to the complex pathophysiological mechanism, spinal cord injury (SCI) has become one of the most intractable central nervous system (CNS) diseases to therapy. Stem cell transplantation, mesenchymal stem cells (MSCs) particularly, appeals to more and more attention along with the encouraging therapeutic results for the functional regeneration of SCI. However, traditional cell transplantation strategies have some limitations, including the unsatisfying survival rate of MSCs and their random diffusion from the injection site to ambient tissues. The application of biomaterials in tissue engineering provides a new horizon. Biomaterials can not only confine MSCs in the injured lesions with higher cell viability, but also promote their therapeutic efficacy. This review summarizes the strategies and advantages of biomaterials reinforced MSCs transplantation to treat SCI in recent years, which are clarified in the light of various therapeutic effects in pathophysiological aspects of SCI. (C) 2021 Shenyang Pharmaceutical University. Published by Elsevier B.V.
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