期刊
CELLS
卷 10, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/cells10030668
关键词
cervical cancer; microRNA; cervical cancer progression
类别
资金
- Sao Paulo Research Foundation (FAPESP) [2016/15831-3]
- PRONON Identificacao de biomarcadores para screening e deteccao precoce de tumores no contexto do Sistema Unico de Saude (SUS)
- CNPq
Through a systematic review of cervical cancer microRNA studies, 26 differentially expressed microRNAs were identified in different stages of cervical cancer development. Findings suggest that some dysregulated microRNAs are associated with specific stages of cervical cancer progression, playing important roles in key cancer hallmarks. These findings also suggest potential for using stage-specific microRNAs as biomarkers for cancer classification and monitoring cervical cancer progression.
To obtain a better understanding on the role of microRNAs in the progression of cervical cancer, a systematic review was performed to analyze cervical cancer microRNA studies. We provide an overview of the studies investigating microRNA expression in relation to cervical cancer (CC) progression, highlighting their common outcomes and target gene interactions according to the regulatory pathways. To achieve this, we systematically searched through PubMed MEDLINE, EMBASE, and Google Scholar for all articles between April 2010 and April 2020, in accordance with the PICO acronym (participants, interventions, comparisons, outcomes). From 27 published reports, totaling 1721 cases and 1361 noncancerous control tissue samples, 26 differentially expressed microRNAs (DEmiRNAs) were identified in different International Federation of Gynecology and Obstetrics (FIGO) stages of cervical cancer development. It was identified that some of the dysregulated microRNAs were associated with specific stages of cervical cancer development. The results indicated that DEmiRNAs in different stages of cervical cancer were functionally involved in several key hallmarks of cancer, such as evading growth suppressors, enabling replicative immortality, activation of invasion and metastasis, resisting cell death, and sustained proliferative signaling. These dysregulated microRNAs could play an important role in cervical cancer's development. Some of the stage-specific microRNAs can also be used as biomarkers for cancer classification and monitoring the progression of cervical cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据