Synapsins and the Synaptic Vesicle Reserve Pool: Floats or Anchors?

In presynaptic terminals, synaptic vesicles (SVs) are found in a discrete cluster that includes a reserve pool that is mobilized during synaptic activity. Synapsins serve as a key protein for maintaining SVs within this reserve pool, but the mechanism that allows synapsins to do this is unclear. This mechanism is likely to involve synapsins either cross-linking SVs, thereby anchoring SVs to each other, or creating a liquid phase that allows SVs to float within a synapsin droplet. Here, we summarize what is known about the role of synapsins in clustering of SVs and evaluate experimental evidence supporting these two models.

Automated summary

Synaptic vesicles are clustered in presynaptic terminals, with a reserve pool that is mobilized during synaptic activity. Synapsins play a key role in maintaining these vesicles within the reserve pool, potentially by either cross-linking them or creating a liquid phase environment.