期刊
CELLS
卷 10, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/cells10051187
关键词
viroids; RNA-directed DNA methylation; small RNAs; RNA interference; epigenetics; bisulfite sequencing
类别
资金
- German Research Foundation (DFG) [Wa1019/14-1]
- Federal Ministry of Education and Research (BMBF) [03180531]
The review discusses the role of Pospiviroidae in the discovery of RdDM, the gradual elucidation of mechanistic details over the years, and proposes a revised RdDM model based on evidence from viroid and non-viroid systems.
Viroids are plant pathogenic, circular, non-coding, single-stranded RNAs (ssRNAs). Members of the Pospiviroidae family replicate in the nucleus of plant cells through double-stranded RNA (dsRNA) intermediates, thus triggering the host's RNA interference (RNAi) machinery. In plants, the two RNAi pillars are Post-Transcriptional Gene Silencing (PTGS) and RNA-directed DNA Methylation (RdDM), and the latter has the potential to trigger Transcriptional Gene Silencing (TGS). Over the last three decades, the employment of viroid-based systems has immensely contributed to our understanding of both of these RNAi facets. In this review, we highlight the role of Pospiviroidae in the discovery of RdDM, expound the gradual elucidation through the years of the diverse array of RdDM's mechanistic details and propose a revised RdDM model based on the cumulative amount of evidence from viroid and non-viroid systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据