期刊
CELLS
卷 10, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/cells10051240
关键词
osteosarcoma; vascular endothelial growth factor A; protein kinase inhibitors; angiogenesis; sarcoma; bone neoplasms
类别
Osteosarcoma is the most common primary tumor of the bones in young adults, with poor prognosis in relapsed or metastatic cases. However, advancements in targeted therapy, particularly focusing on angiogenesis, have shown promise in enhancing anti-tumor activity in osteosarcoma patients.
Osteosarcoma is the most common primary tumor of the bones affecting mainly young adults. Despite the advances in the field of systemic anticancer therapy, the prognosis of relapsed of metastatic osteosarcoma patients remain dismal with very short survival. However, the better understanding of the pathophysiology of this subtype of sarcoma has led to the identification of new targeted agents with significant activity. In fact, increased angiogenesis plays a major role in the tumor growth and survival of osteosarcoma patients. Several targeted agents have demonstrated a significant anti-tumor activity including multi-kinase inhibitors. In this review, we will discuss the pathophysiology, rationale, and role of targeting angiogenesis via the VEGF pathway in patients with osteosarcoma with emphasis on the published clinical trials and future directions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据