Oral-Gut Microbiome Axis in Gastrointestinal Disease and Cancer

Simple Summary Microbiota dysbiosis is correlated with numerous diseases in the human body. To date, the research on the microbiome-associated diseases been focused on an organ-specific microbiome. However, the interorgan microbial network is emerging as an important regulator in physiological functions and pathological processes. The oral cavity and gut are the two largest microbial ecosystems. Recent studies have demonstrated that the oral-to-gut and gut-to-oral microbial transmission can regulate pathogenesis, indicating the presence of the oral-gut microbiome axis. Here, we will review the role of the oral-gut microbiome axis in gastrointestinal disease and cancer, which may provide insight for precise diagnosis/prognosis and effective treatment. It is well-known that microbiota dysbiosis is closely associated with numerous diseases in the human body. The oral cavity and gut are the two largest microbial habitats, playing a major role in microbiome-associated diseases. Even though the oral cavity and gut are continuous regions connected through the gastrointestinal tract, the oral and gut microbiome profiles are well-segregated due to the oral-gut barrier. However, the oral microbiota can translocate to the intestinal mucosa in conditions of the oral-gut barrier dysfunction. Inversely, the gut-to-oral microbial transmission occurs as well in inter- and intrapersonal manners. Recently, it has been reported that oral and gut microbiomes interdependently regulate physiological functions and pathological processes. Oral-to-gut and gut-to-oral microbial transmissions can shape and/or reshape the microbial ecosystem in both habitats, eventually modulating pathogenesis of disease. However, the oral-gut microbial interaction in pathogenesis has been underappreciated to date. Here, we will highlight the oral-gut microbiome crosstalk and its implications in the pathogenesis of the gastrointestinal disease and cancer. Better understanding the role of the oral-gut microbiome axis in pathogenesis will be advantageous for precise diagnosis/prognosis and effective treatment.

Automated summary

Microbiota dysbiosis is closely associated with various diseases in the human body, with the oral cavity and gut serving as the two major microbial habitats that play crucial roles in disease pathogenesis. Despite the well-segregated oral and gut microbiome profiles due to the oral-gut barrier, microbial transmissions between these two regions can shape and modulate the microbial ecosystem, ultimately influencing disease pathogenesis. Understanding the interplay of the oral-gut microbiome axis in disease development can offer insights for precise diagnosis, prognosis, and effective treatment strategies.