Radiomics in Renal Cell Carcinoma-A Systematic Review and Meta-Analysis

Simple Summary Radiomics may answer questions where the conventional interpretation of medical imaging has limitations. The aim of our systematic review and meta-analysis was to assess the (current) status of evidence in the application of radiomics in the field of renal masses. We focused on its role in diagnosis, sub-entity discrimination and treatment response assessment in renal cell carcinoma (RCC) and benign renal masses. Our quantitative synthesis showed promising results in discrimination of tumor dignity, nevertheless, the value added to human assessment remains unclear and should be the focus of future research. Furthermore, the benefit regarding treatment response assessment remains unclear as well, since the existing studies are investigating already abandoned systemic therapies (ST), which no longer represent the current reference standard. Open science could enable to establish technical and clinical validity of radiomic signatures prior to the incorporation of radiomics into everyday clinical practice. Radiomics may increase the diagnostic accuracy of medical imaging for localized and metastatic RCC (mRCC). A systematic review and meta-analysis was performed. Doing so, we comprehensively searched literature databases until May 2020. Studies investigating the diagnostic value of radiomics in differentiation of localized renal tumors and assessment of treatment response to ST in mRCC were included and assessed with respect to their quality using the radiomics quality score (RQS). A total of 113 out of 1098 identified studies met the criteria and were included in qualitative synthesis. Median RQS of all studies was 13.9% (5.0 points, IQR 0.25-7.0 points), and RQS increased over time. Thirty studies were included into the quantitative synthesis: For distinguishing angiomyolipoma, oncocytoma or unspecified benign tumors from RCC, the random effects model showed a log odds ratio (OR) of 2.89 (95%-CI 2.40-3.39, p < 0.001), 3.08 (95%-CI 2.09-4.06, p < 0.001) and 3.57 (95%-CI 2.69-4.45, p < 0.001), respectively. For the general discrimination of benign tumors from RCC log OR was 3.17 (95%-CI 2.73-3.62, p < 0.001). Inhomogeneity of the available studies assessing treatment response in mRCC prevented any meaningful meta-analysis. The application of radiomics seems promising for discrimination of renal tumor dignity. Shared data and open science may assist in improving reproducibility of future studies.

Automated summary

Radiomics may have the potential to improve the discrimination of tumor dignity in renal masses, but its benefit in treatment response assessment remains unclear. Future studies should focus on clarifying the added value of radiomics in human assessment. Open science and shared data could enhance the reproducibility of studies in this field.