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CANCER RESEARCH (2009)
Roles and regulation of secretory and lysosomal acid sphingomyelinase
Russell W. Jenkins et al.
CELLULAR SIGNALLING (2009)
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
Susan Pyne et al.
CELLULAR SIGNALLING (2009)
Impact of Natural Products on Developing New Anti-Cancer Agents
Gordon M. Cragg et al.
CHEMICAL REVIEWS (2009)
Interleukin-1 Regulates the Expression of Sphingosine Kinase 1 in Glioblastoma Cells
Barbara S. Paugh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Bioactive sphingolipids: metabolism and function
Nana Bartke et al.
JOURNAL OF LIPID RESEARCH (2009)
Sphingosine-1-Phosphate Regulates Glioblastoma Cell Invasiveness through the Urokinase Plasminogen Activator System and CCN1/Cyr61
Nicholas Young et al.
MOLECULAR CANCER RESEARCH (2009)
Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors
Florian Mullershausen et al.
NATURE CHEMICAL BIOLOGY (2009)
Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
Nitai C. Hait et al.
SCIENCE (2009)
Regulation and functions of sphingosine kinases in the brain
Lauren Bryan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2008)
Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK
Alina Felicia Nica et al.
CELL CYCLE (2008)
The sphingolipid salvage pathway in ceramide metabolism and signaling
Kazuyuki Kitatani et al.
CELLULAR SIGNALLING (2008)
Targeting SphK1 as a new strategy against cancer
Dai Shida et al.
CURRENT DRUG TARGETS (2008)
Natural products in drug discovery
Alan L. Harvey
DRUG DISCOVERY TODAY (2008)
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a come-and-get-me signal
David R. Gude et al.
FASEB JOURNAL (2008)
Principles of bioactive lipid signalling: lessons from sphingolipids
Yusuf A. Hannun et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets
K. Takabe et al.
PHARMACOLOGICAL REVIEWS (2008)
FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma
Qing Liu et al.
BLOOD (2008)
Ceramide traffic in C6 glioma cells: Evidence for CERT-dependent and independent transport from ER to the Golgi apparatus
Paola Giussani et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2008)
Tumor cell apoptosis polarizes macrophages -: Role of sphingosine-1-phosphate
Andreas Weigert et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Autocrine and paracrine roles of sphingosine-1-phosphate
Sergio E. Alvarez et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2007)
Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2
Guo Ding et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration
Frauke Doell et al.
ENDOCRINE-RELATED CANCER (2007)
Deletion of the Sphingosine Kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes
Rong Tao et al.
CARDIOVASCULAR RESEARCH (2007)
Regulation and functional roles of sphingosine kinases
Regina Alemany et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2007)
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
Nitai C. Hait et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2006)
Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
B Visentin et al.
CANCER CELL (2006)
FTY720: A promising agent for treatment of metastatic hepatocellular carcinoma
TK Lee et al.
CLINICAL CANCER RESEARCH (2005)
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
M Maceyka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma
JWY Ho et al.
MOLECULAR CANCER THERAPEUTICS (2005)
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance
H Yasui et al.
CANCER RESEARCH (2005)
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: Roles of sphingosine kinase isoforms in growth of glioblastoma cell lines
JR Van Brocklyn et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
SM Pitson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?
C Bionda et al.
BIOCHEMICAL JOURNAL (2004)
Membrane lipids and vesicular traffic
G van Meer et al.
CURRENT OPINION IN CELL BIOLOGY (2004)
Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-β and mediates TIMP-1 up-regulation
M Yamanaka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells
D Shida et al.
FEBS LETTERS (2004)
Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
N Igarashi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
SM Pitson et al.
EMBO JOURNAL (2003)
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis
H Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment
H Azuma et al.
JOURNAL OF UROLOGY (2003)
Regulation of death receptor signaling and apoptosis by ceramide
E Gulbins
PHARMACOLOGICAL RESEARCH (2003)
Pachastrissamine, a cytotoxic anhydrophytosphingosine from a marine sponge, Pachastrissa sp.
I Kuroda et al.
JOURNAL OF NATURAL PRODUCTS (2002)
Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors
S Siehler et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2002)
Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-α signaling
P Xia et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine
DB Jendiroba et al.
LEUKEMIA RESEARCH (2002)
Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8):: Structure-activity relationship of sphingosine1-phosphate receptors
DS Im et al.
BIOCHEMISTRY (2001)
Ceramide glycosylation potentiates cellular multidrug resistance
YY Liu et al.
FASEB JOURNAL (2001)
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
H Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution
AJ Melendez et al.
GENE (2000)
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